Robert McGrathflipped into CANCER 2.0Adenovirus Oncolytic adenovirus programmed by synthetic gene circuit for cancer inature.com - Huiya Huang, Yiqi Liu, Weixi Liao, Yubing Cao, Qiang Liu, Yakun Guo, Yinying Lu, Zhen Xie Improving efficacy of oncolytic virotherapy remains challenging due to difficulty increasing specificity and immune responses against cancer and …
IKITOflipped into Healthy LivingIcon version of the Flipboard logoCancer Novel study documents marked slowdown of cell division rates in old age | EurekAlert! Science Newseurekalert.org Clearer understanding of lower cell replication rates in old age may have implications for preventing cancer and slowing aging In a novel study …
Grey Cup CFL Simulation: Riders are on the rise after latest win -cfl.ca - CFL.ca Staff TORONTO — While the top two teams in the West Division were closely matched when it came to the CFL Simulation a week ago, one team received a …
Nature ER-shaping atlastin proteins act as central hubs to promote flavivirusnature.com - www.nature.com Flavivirus infection leads to a rearrangement of host cell ER membranes that creates an environment permissive to viral replication. The morphology …
Oscar Seguradoflipped into Genomics & Gene Therapy 101Science Scientists unwind mystery behind DNA replicationphys.org - Cornell University The molecules of life are twisted. But how those familiar strands in DNA's double helix manage to replicate without being tangled up has been hard to …
HIV Resident memory T cells are a cellular reservoir for HIV in the cervicnature.com - Jon Cantero-Pérez, Judith Grau-Expósito, Carla Serra-Peinado, Daniela A. Rosero, Laura Luque-Ballesteros, Antonio Astorga-Gamaza, Josep Castellví, Tamara Sanhueza, Gustavo Tapia, Belen Lloveras, Marco A. Fernández, Julia G. Prado, Josep M. Solé-Sedeno, Antoni Tarrats, Carla Lecumberri, Laura Mañalich-Barrachina, Cristina Centeno-Mediavilla, Vicenç Falcó, Maria J. Buzon, Meritxell Genescà Chun, T. W. et al. Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. Proc. Natl Acad. Sci. …
Icon version of the Flipboard logoData Science “Here’s an interesting story right in your sweet spot” « Statistical Modeling, Causal Inference, and Social Sciencecolumbia.edu - statmodeling.stat.columbia.edu Large effects from something whose possible effects couldn’t be that large? Check. Finding something in a sample of 1024 people that requires 34,000 …
Icon version of the Flipboard logoPhilosophy of Science What is a replication? - Philsci-Archivepitt.edu - philsci-archive.pitt.edu This article develops a new, general account of replication (“the Resampling Account of replication”): I argue that a replication is an experiment …
Icon version of the Flipboard logoData Science The status-reversal heuristic « Statistical Modeling, Causal Inference, and Social Sciencecolumbia.edu - statmodeling.stat.columbia.edu Awhile ago we came up with the time-reversal heuristic, which was a reaction to the common situation that there’s a noisy study, followed by an …
Nuclear Energy Transportin-1 binds to the HIV-1 capsid via a nuclear localization signature.com - Juliette Fernandez, Anthony K. Machado, Sébastien Lyonnais, Célia Chamontin, Kathleen Gärtner, Thibaut Léger, Corinne Henriquet, Camille Garcia, Débora M. Portilho, Martine Pugnière, Laurent Chaloin, Delphine Muriaux, Yohei Yamauchi, Mickaël Blaise, Sébastien Nisole, Nathalie J. Arhel Campbell, E. M. & Hope, T. J. HIV-1 capsid: the multifaceted key player in HIV-1 infection. Nat. Rev. Microbiol. 13, 471–483 (2015). Ambrose, Z. & …
Adeflipped into HealthDNA Mitochondrial Aging Theory Is A Myth: Aging Lies In The NucleusMashable - Afiya QureshiFor almost half a century, it was thought that mitochondrial DNA (mtDNA) and oxidative stress were the major contributors to aging. This theory was postulated by Harman in the 70’s, where two independent
Icon version of the Flipboard logoPsychologyBeyond the 'replication crisis,' does research face an 'inference crisis'? Researchers test expert inferences against knownsciencedaily.com - University of Massachusetts at Amherst For the past decade, social scientists have been unpacking a 'replication crisis' that has revealed how findings of an alarming number of scientific …
Science Reward PhDs’ high-quality, slow sciencenature.com - www.nature.com Publishing novel, eye-grabbing results is rewarded in academia; whether publishing robust replications will be rewarded by graduation committees and …
Gene Expression Viral N 6 -methyladenosine upregulates replication and pathogenesis ofnature.com - Miaoge Xue, Boxuan Simen Zhao, Zijie Zhang, Mijia Lu, Olivia Harder, Phylip Chen, Zhike Lu, Anzhong Li, Yuanmei Ma, Yunsheng Xu, Xueya Liang, Jiyong Zhou, Stefan Niewiesk, Mark E. Peeples, Chuan He, Jianrong Li N6-methyladenosine (m6A) is the most prevalent internal modification of mRNAs in most eukaryotes. Here we show that RNAs of human respiratory …
Oscar Seguradoflipped into Genomics & Gene Therapy 101Science How chromosomes change their shape during cell differentiationphys.org - RIKEN The human genome is made up of 46 chromosomes, each of which has a length of about 100 to 200 million base pairs, the building blocks of the DNA …
IKITOflipped into Healthy LivingIcon version of the Flipboard logoMitochondrial DNA New study challenges our understanding of premature ageing | EurekAlert! Science Newseurekalert.org Disturbances in the function of mitochondrial DNA can accelerate the ageing process in ways that are different than previously thought, according to …
Aging Age is in the nucleusnature.com - www.nature.com Nuclear DNA damage has detrimental effects on cellular homoeostasis and accelerates the ageing process. A new study causally links error-prone …
Icon version of the Flipboard logoData Science My talk at the Brookings Institution this Fri 11am « Statistical Modeling, Causal Inference, and Social Sciencecolumbia.edu - statmodeling.stat.columbia.edu The replication crisis in science: Does it matter for policy? Andrew Gelman, Department of Statistics and Department of Political Science, Columbia …
Nuclear Energy mtDNA robs nuclear dNTPsnature.com - www.nature.com Hämäläinen, R. H. et al. Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying …
Mutations Defects in mtDNA replication challenge nuclear genome stability througnature.com - www.nature.com Increased mitochondrial DNA (mtDNA) replication frequency is shown to lead to defects in maintenance of the nuclear genome due to reallocation of …
News18.comflipped into News18 Latest NewsViruses Protein Essential for Chikungunya Virus Replication Identifiednews18.com - Trending Desk According to researchers, while the clinical manifestations of the disease are well understood the mechanisms by which the virus infects human cells …
Donald Trump James Strong Show Podcast 142 Amber Guyger, Incels and Donald Trumpspreaker.com - James Strong After a briefing about Amber Guyger and Involuntary Celibates, Strong shines light on Donald Trump and his enemies list. It's long, involved. And …
Icon version of the Flipboard logoProtein A catalog of DNA replication proteinsphys.org - Leigh MacMillan Maintenance of genome integrity—and prevention of diseases such as cancer—requires complete and faithful replication of the genome every cell …
Zika Virus Resveratrol affects Zika virus replication in vitronature.com - Azirah Mohd, Nurhafiza Zainal, Kim-Kee Tan, Sazaly AbuBakar Kindhauser, M. K., Allen, T., Frank, V., Santhana, R. S. & Dye, C. Zika: the origin and spread of a mosquito-borne virus. Bull. World Health Organ. 94, …
Flu How the influenza virus achieves efficient viral RNA replicationphys.org - Public Library of Science New insights on how subunits of the influenza virus polymerase co-evolve to ensure efficient viral RNA replication are provided by a study published …
Newsyflipped into NewsyScience The Social Science Studies That Can't Be Replicatednewsy.com - Chance Seales The veracity of a finding depends on whether other researchers can reproduce it. Just for fun, let's suppose it's a few hundred years ago and you've …
New Scientistflipped into New ScientistPsychology Common sense can predict if a psychology study will ever be replicated | New Scientistnewscientist.com - By Leo Benedictus Social science and experimental psychology are still shaking from the “replication crisis”, an embarrassing decade that revealed that the results of …
Nazneen Rahmanflipped into Medical InnovationsScience New study discovers the three-dimensional structure of the genome replication machinephys.org - The Mount Sinai Hospital Mount Sinai researchers have discovered how the enzyme DNA polymerase delta works to duplicate the genome that cells hand down from one generation to …
DNA Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holnature.com - Rinku Jain, William J. Rice, Radhika Malik, Robert E. Johnson, Louise Prakash, Satya Prakash, Iban Ubarretxena-Belandia, Aneel K. Aggarwal Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S. A major role of DNA polymerase delta in replication of both the leading and lagging DNA …
Genes Transcriptome Sequencing of Peripheral Blood Mononuclear Cells from Elnature.com - Francisco Díez-Fuertes, Humberto Erick De La Torre-Tarazona, Esther Calonge, Maria Pernas, María del Mar Alonso-Socas, Laura Capa, Javier García-Pérez, Anavaj Sakuntabhai, José Alcamí Deeks, S. G. & Walker, B. D. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. …
