Methylation

Methylation in cell-free DNA for early cancer detection | Annals of Oncology

Liquid biopsies and, in particular, analysis of cell-free DNA (cfDNA), have emerged as a promising and potentially transformative non-invasive …

Cancer

Can a Parent’s Life Experience Change the Genes a Child Inherits?

Inside the controversial world of epigenetics research<p>“Tim over here has the original Linnaeus flower.”<p>I had come to Cold Spring Harbor National Laboratory for its plants. A transplanted Englishman named Robert Martienssen met me in front of his lab, and we spent the morning admiring his mats of …

Biology

Researchers Discover How Key Genetic Risk Factor for MS Operates

Scientists have uncovered the molecular mechanism by which the genetic variant <i>HLA-DRB1*15:01</i> is the strongest risk factor for multiple sclerosis, new …

Genetics

Deep data dive helps predict cerebral palsy

When University of Delaware molecular biologist Adam Marsh was studying the DNA of worms living in Antarctica's frigid seas to understand how the …

Genetics

Researchers diagnose cerebral palsy using AI and next-generation sequencing

Researchers have shown that patients with spastic cerebral palsy (CP) can be identified using DNA methylation patterns in circulating blood cells.

Next-Generation Sequencing

An epigenome-wide association study meta-analysis of educational attainment

Altmetric: 40<p>More detail<p>Immediate Communication |<p>Open | Published: 31 October 2017<p>R Karlsson Linnér<br>• , R E Marioni<br>• , C A Rietveld<br>• , A J Simpkin<br>• , N M …

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NR3C1 hypermethylation in depressed and bullied adolescents

Altmetric: 1<p>More detail<p>Article |<p>Open | Published: 19 June 2018<p>Paschalis Efstathopoulos,<br>• Filip Andersson,<br>• Philippe A. Melas ORCID: …

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Single-cell multi-omics sequencing of human early embryos

Resource | Published: 18 June 2018<p>Lin Li,<br>• Fan Guo ORCID: orcid.org/0000-0002-0165-073X,<br>• Yun Gao,<br>• Yixin Ren,<br>• Peng Yuan,<br>• Liying Yan ORCID: …

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Epigenetic regulation of the oxytocin receptor is associated with neural response during selective social attention

Altmetric: 1<p>More detail<p>Article |<p>Open | Published: 15 June 2018<p>Meghan H. Puglia,<br>• Jessica J. Connelly &<br>• James P. Morris<p><i>Translational Psychiatry</i><b>volume 8</b>, …

Neurology

Leptin Expression and Gene Methylation Patterns in Alcohol-Dependent Patients with Ethyltoxic Cirrhosis—Normalization After Liver Transplantation and Implications for Future Research | Alcohol and Alcoholism

Aims<p>Liver transplantation is the only curative treatment available for patients with end-stage alcoholic liver disease. As different studies showed a …

Diabetes

CancerDetector: ultrasensitive and non-invasive cancer detection at the resolution of individual reads using cell-free DNA methylation sequencing data | Nucleic Acids Research

The detection of tumor-derived cell-free DNA in plasma is one of the most promising directions in cancer diagnosis. The major challenge in such an …

Genetics

Epigenomics and metabolomics reveal the mechanism of the APOA2 -saturated fat intake interaction affecting obesity | The American Journal of Clinical Nutrition

Background<p>The putative functional variant −265T>C (rs5082) within the <i>APOA2</i> promoter has shown consistent interactions with saturated fatty acid (SFA) …

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Coral Might Be Adjusting Its DNA to Survive Warming Oceans

Methylation changes how DNA is read. Coral might be doing it on its own.<p>Coral across the globe are facing tremendous challenges due to climate change. Scientists in Saudi Arabia have begun looking at a process that changes the regulation of genes called DNA methylation to see if coral can adapt to …

Science

Coral tricks for adapting to ocean acidification

A process that changes the regulation of genes could help corals acclimatize to the impacts of global warming.

Genetics

Transposon-associated epigenetic silencing during Pleurotus ostreatus life cycle | DNA Research

Transposable elements constitute an important fraction of eukaryotic genomes. Given their mutagenic potential, host-genomes have evolved epigenetic …

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Tissue-specific DNA demethylation after birth

Because of changes in their environment, including the need to repair tissue, cells cannot remain static. They must do their job even if conditions …

Genetics

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease | Human Molecular Genetics

We have undertaken a systematic Mendelian randomization (MR) study using methylation quantitative trait loci (meQTL) as genetic instruments to assess …

Genetics

Epigenome-associated phenotypic acclimatization to ocean acidification in a reef-building coral

Abstract<p>There are increasing concerns that the current rate of climate change might outpace the ability of reef-building corals to adapt to future …

Biology

An evolutionary adaptation that doesn’t directly rely on new mutations

Blind cave fish harnessed an epigenetic system to shut down eye development.<p>Creatures that spend their lives in dark caves tend to be changed by the …

Biology

DNA methylation as a marker for prenatal smoke exposure in adults | International Journal of Epidemiology

Background<p>Prenatal smoke exposure is known to be robustly associated with DNA methylation among offspring in early life, but whether the association …

Medicine

Seeing the light using blind cavefish | Nature Research Ecology & Evolution Community

The paper in Nature Ecology & Evolution is here: https://go.nature.com/2L7tDLJ<p>It was 2015 and we had just submitted the revised version of a study on …

Biology

survey of transcriptome complexity in Sus scrofa using single-molecule long-read sequencing | DNA Research

Alternative splicing (AS) and fusion transcripts produce a vast expansion of transcriptomes and proteomes diversity. However, the reliability of …

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Isospecific adenine DNA methyltransferases show distinct preferences towards DNA substrates

Altmetric: 0<p>More detail<p>Article |<p>Open | Published: 29 May 2018<p>Ewa Wons,<br>• Iwona Mruk &<br>• Tadeusz Kaczorowski<p><i>Scientific Reports</i><b>volume 8</b>, Article number: 8243 …

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Sex differences in the methylome and transcriptome of the human liver and circulating HDL-cholesterol levels | The Journal of Clinical Endocrinology & Metabolism

Context<p>Epigenetics may contribute to sex-specific differences in human liver metabolism.<p>Objective<p>To study the impact of sex on DNA methylation and …

Genetics

How do insects survive on a sugary diet? Study offers clues to how aphids capitalize on relationship with beneficial bacteria through changes in gene expression linked to DNA methylation

Study offers clues to how aphids capitalize on relationship with beneficial bacteria through changes in gene expression linked to DNA …

Biology

Identification of rare de novo epigenetic variations in congenital disorders

Altmetric: 56<p>More detail<p>Article |<p>Open<p>Mafalda Barbosa,<br>• Ricky S. Joshi,<br>• Paras Garg,<br>• Alejandro Martin-Trujillo,<br>• Nihir Patel ORCID: …

Genetics

DNA Methylation: Can Your Diet Reduce Your Risk of Disease?

DNA methylation is an example of one of the many mechanisms of epigenetics. Epigenetics refers to inheritable changes in your DNA that don’t change …

Genetics

How do insects survive on a sugary diet?

Study offers clues to how aphids capitalize on relationship with beneficial bacteria through changes in gene expression linked to DNA …

Biology

Space-like gravity weakens biochemical signals in muscle formation

While space exploration, astronomers go through different types of physiological changes including lower muscle mass and slower muscle development. …

Genetics

Space-like gravity weakens biochemical signals in muscle formation: Microgravity conditions affect DNA methylation of muscle cells, slowing their differentiation

Microgravity conditions affect DNA methylation of muscle cells, slowing their differentiation<p>Microgravity conditions affect DNA methylation of muscle …

Genetics