Thasso Post Magazine

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Childhood brain tumors: Genetic variability amenable to individualized therapy approaches

<b>October 02, 2017 –</b> Seemingly incurable childhood brain tumor is one of the most devastating clinical diagnosis a young patient and her/his family can …

Cancer

Chagas disease: First time approval of a treatment in the US

<b>August 31, 2017 –</b> For the very first time, the American Food & Drug Administration (FDA) granted approval for a treatment of Chagas disease in the …

Lifeomics: Epigenetic DNA methylation-based life insurance?

<b>Mai 07, 2017 –</b> Genetics- and/or genomics-based approaches are penetrating every single aspect of human life. In contrast to the term <b>theragenomics</b> …

Bisphosphonates: GGPS1 Mutation and Atypical Femoral Fractures

<b>May 05, 2017 –</b> This report nicely illustrates how, by both clever study design and selection of according phenotypic patients, genetic …

Risk of severe if not fatal skin reactions with Pembrolizumab (Keytruda)

Healthcare professionals including oncologists, nurses, hospital pharmacists, emergency room staff, and cancer clinic staff should <b>i)</b> counsel patients …

CDH2 gene to cause sudden death in young people

“This is important news for families who have had a young family member suffer a sudden cardiac death, for them to know a genetic cause has been …

Brodalumab (Siliq) with a fatal touch: New psoriasis drug approved

<b>February 16, 2017 –</b> The American Food & Drug Administration (FDA) just approved Brodalumab (Siliq) to treat adults with moderate-to-severe plaque …

Genetic predisposition and sweating: Most Koreans don't have to wear deodorants

<b>February 08, 2017 –</b> Genetic predisposition may go in both ways, the positive and the negative. Usually, when we talk about genetic predisposition, …

Massaging of data and outcomes: Can we ever trust clinical trial outcomes reported by Pharma?

Paroxetine is prescribed for depression, anxiety, panic attacks, post-traumatic stress disorder (PSTD), obsessive compulsive disorder (OCD), and most …

Orlistat: Assessment of Adverse Events in Protocols, Clinical Study Reports, and Published Papers

Orlistat (Xenical)<p><b>August 30, 2016 –</b> The present article which just appeared in August 2016 issue of PLOS Medicine illustrates how the inaccurate and …

Eltrombopag (Revolade) can cause severe hepatotoxicity and potentially fatal liver injury

<b>August 26, 2016 –</b> Eltrombopag is a medication that has been developed for certain conditions that lead to thrombocytopenia (abnormally low platelet …

Precision Medicine Initiative: draft guidances issued

Powerful new technologies, known as next generation sequencing (NGS), can scan a person’s DNA to detect genomic variations that may determine <b>i)</b> …

Aspirin: Does OTC mean without serious health risks?

In 2009, a warning about the risk of serious bleeding was added to the labels of all OTC products that contain NSAIDs, including aspirin-containing …

Are first-in-man (FIM) clinical trials unsafe?

Thus, EMA has started a review of the guidelines currently applicable that describe first-in-man (FIM) clinical trials and the data needed to enable …

We knew it all along: It's all in the genes, and success in dating is no exception

Human Nature<p>The research team wanted to find out if mate selection could actually be influenced by people’s ability to quickly detect socially …

Hope for patients with urothelial carcinoma

<b>May 18, 2016 –</b> Over the last two years, biologics targeting the PD-1/PD-L1 pathway (proteins found on the body’s immune cells and some cancer cells), …

Pimavanserin (Nuplazid) for Parkinson's Disease

Seeing things that are not there<p>Hallucinations or delusions can occur in as many as 50 percent of patients with Parkinson’s disease at some time …

The betrayed educated patient

<b>May 01, 2016 –</b> The present post addresses a very disturbing issue in connection with clinical trials and the disclosure of the results in public. The …

Zika virus, microcephaly, and other birth defects

A comparison of a typical head size for a baby and a baby with microcephaly.<p><b>April 14, 2016 –</b> This post is based on materials provided by U.S. Centers …

Venetoclax (Venclexta) for the treatment of CLL

<b>April 12, 2016 –</b> The American Food and Drug Administration (FDA) just approved Venetoclax (Venclexta) for the treatment of patients with chronic …

Opioid risks : FDA announces enhanced warnings

“Opioid addiction and overdose have reached epidemic levels over the past decade, and the FDA remains steadfast in our commitment to do our part to …

Under scrutiny: The EMA reviews Idelalisib (Zydelig)

The review has been started because an increased rate of serious adverse events including deaths, mostly due to infections, was seen in three …

HCV care: Are there ethical and societal issues looming?

Recent clinical trials have demonstrated that new, simple-to-use treatment regimens for persons living with HCV infection are safe and highly …

Ixekizumab (Taltz) for plaque psoriasis

<b>March 04, 2016 –</b> On February 25, 2016, the Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the …

News for Obinutuzumab (Gazyva) and Everolimus (Afinitor)

Ph.D.; Professor in Pharmacology and Toxicology. Senior expert in theragenomic and personalized medicine and individualized drug safety. Senior …

Epilepsy: Brivaracetam (Briviact) approved

Brivaracetam<p><b>February 19, 2016 –</b> Epilepsy is a brain disorder that causes people to have recurring seizures. A seizure is an episode, usually of …

Osimertinib (Tagrissa) for NSCLC with EGFR T790M

To be eligible for Osimertinib (Tagrissa) treatment, patients must undergo diagnostic testing that uses either tumor tissue or plasma to establish …

Eribulin Mesylate (Halaven)

The American Food and Drug Administration just approved Eribulin Mesylate (Halaven), a type of chemotherapy, for the treatment of liposarcoma that …