PLOS Pathogens Pearls

@PLOSPearls | 7 Magazines | 493 Articles | 554 Followers | PLOS Pathogens presents an Open Access compendium of "lessons-that-last." This living collection of short, educational, and highly useful articles addresses topics of relevance and importance within the wide-ranging field of pathogens research, with insights tailored to graduate students and post-docs.

Chemical Signals and Mechanosensing in Bacterial Responses to Their Environment

by Akshay K. Harapanahalli, Jessica A. Younes, Elaine Allan, Henny C. van der Mei, Henk J. Busscher

Gene Expression

Plasticity and Redundancy in Proteins Important for Toxoplasma Invasion

1. de Koning-Ward TF, Gilson PR, Crabb BS. Advances in molecular genetic systems in malaria. Nat Rev Microbiol. 2015;13(6):373–87. doi: …

Life Sciences

Are Human Intestinal Eukaryotes Beneficial or Commensals?

1. Parfrey LW, Walters WA, Knight R (2011). Microbial eukaryotes in the human microbiome: Ecology, evolution, and future directions. Front Cell …


Riding the R Train into the Cell

by Daniel DiMaio, Christopher G. Burd, Kylia Goodner


Fungi That Infect Insects: Altering Host Behavior and Beyond

by Yanfang Shang, Peng Feng, Chengshu Wang


Illuminating Targets of Bacterial Secretion

by Roger D. Pechous, William E. Goldman


N-acetylglucosamine Regulates Virulence Properties in Microbial Pathogens

1. Kombrink A, Thomma BP. LysM effectors: secreted proteins supporting fungal life. PLoS Pathog. 2013;9(12):e1003769. doi: …

E. Coli

Periodontal Diseases: Bug Induced, Host Promoted

by Shariq A. Khan, Eric F. Kong, Timothy F. Meiller, Mary Ann Jabra-Rizk

Systematic Reviews

On and Under the Skin: Emerging Basidiomycetous Yeast Infections Caused by Trichosporon Species

1. Sugita T Trichosporon behrend (1890). in: Kurtzman C.P., Fell J.W., Boekhout T. (Eds.) The yeasts: a taxonomic study. 5th ed. Elsevier Science, …

Life Sciences

Mechanisms of Host Behavioral Change in Toxoplasma gondii Rodent Association

1. Adamo SA. Parasites: evolution's neurobiologists. J Exp Biol. 2013 Jan 1;216(Pt 1):3–10. doi: 10.1242/jeb.073601. pmid:23225861

2. Flegr J. …

National Academy of Sciences

Turning Up the Heat: Inflammasome Activation by Fungal Pathogens

by Aldo Henrique Tavares, Pedro Henrique Bürgel, Anamélia Lorenzetti Bocca

Cross Kingdom Activators of Five Classes of Bacterial Effectors

1. Anderson DM, Schmalzer KM, Sato H, Casey M, Terhune SS, Haas AL, et al. Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas

The Emerging Role for RNA Polymerase II in Regulating Virulence Gene Expression in Malaria Parasites

by Uchechi E. Ukaegbu, Kirk W. Deitsch


Exploiting Fungal Virulence-Regulating Transcription Factors As Novel Antifungal Drug Targets

by Yong-Sun Bahn


RNA Virus Reassortment: An Evolutionary Mechanism for Host Jumps and Immune Evasion

by Dhanasekaran Vijaykrishna, Reshmi Mukerji, Gavin J. D. Smith


The Lung Microbiome: New Principles for Respiratory Bacteriology in Health and Disease

1. Horikoshi K, Grant WD (1998) Extremophiles: Microbial Life In Extreme Environments: Wiley-Liss.

2. Gleeson K, Eggli DF, Maxwell SL Quantitative …

Deploying FLAREs to Visualize Functional Outcomes of Host—Pathogen Encounters

by Lena J. Heung, Anupam Jhingran, Tobias M. Hohl

Immune System

Extracellular Virions: The Advance Guard of Poxvirus Infections

by David J. Pickup

National Academy of Sciences

Risks of Antibiotic Exposures Early in Life on the Developing Microbiome

1. Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R (2011) Development of the Human Gastrointestinal Microbiota and Insights From High-Throughput …

Exploring Host–Pathogen Interactions through Biological Control

1. Moscardi F. Assessment of the application of baculoviruses for control of Lepidoptera. Annu Rev Entomol. 1999;44: 257–289. pmid:15012374

2. …

Host Delivery of Favorite Meals for Intracellular Pathogens

1. Rohmer L, Hocquet D, Miller SI. Are pathogenic bacteria just looking for food? Metabolism and microbial pathogenesis. Trends Microbiol. …

Waterborne Viruses: A Barrier to Safe Drinking Water

by Aimee M. Gall, Benito J. Mariñas, Yi Lu, Joanna L. Shisler

Drinking Water

Is Development of a Vaccine against Cryptococcus neoformans Feasible?

by Chrissy M. Leopold Wager, Floyd L. Wormley


Successes and Challenges on the Road to Cure Hepatitis C

by Stacy M. Horner, Susanna Naggie


Analysis of Bottlenecks in Experimental Models of Infection

1. Reece JB (2014) Campbell biology. Tenth edition. Boston: Pearson.

2. Levin BR (1981) Periodic selection, infectious gene exchange and the genetic …

Archaea in and on the Human Body: Health Implications and Future Directions

by Mor N. Lurie-Weinberger, Uri Gophna

Life Sciences

Battling Phages: How Bacteria Defend against Viral Attack

by Kimberley D. Seed


Expected and Unexpected Features of the Newly Discovered Bat Influenza A-like Viruses

by Wenjun Ma, Adolfo García-Sastre, Martin Schwemmle


Adenovirus Tales: From the Cell Surface to the Nuclear Pore Complex

by Eric J. Kremer, Glen R. Nemerow

A 21st Century Perspective of Poliovirus Replication

by Nicolas Lévêque, Bert L. Semler