Noncommunicable diseases (NCDs) are responsible for two-thirds of the world's deaths, one-fourth of which occur before the age of 60. Nearly 80% of NCD deaths occur in low- and middle-income countries, where they are also increasing most rapidly. With these global needs and disparities in mind, the editors of PLOS Medicine issued a call for papers into research and commentary on NCDs directed toward improving population health and reducing health disparities. For this theme, we include as part of the definition of NCD research the identification, treatment, and prevention of mental health and substance use disorders, as both cause considerable morbidity and mortality, contribute to NCDs, and similarly require the health systems necessary to care for chronic conditions.
This Collection brings together research and commentary published in PLOS Medicine that examines the global challenges and opportunities for addressing noncommunicable disease around the world.