Stem Forward

By Mike Bracco | Interesting articles covering the topics of Stem Cell Research, Regenerative Medicine and Synthetic Biology with an emphasis on the near term opportunities to improve the quality and longevity of our lives which are backed up by high quality peer reviewed research

How to reduce brain inflammation with a keto diet

New research uncovers and replicates the mechanism by which a ketogenic diet curbs brain inflammation. The findings pave the way for a new drug …

New CRISPR tools enable extraordinarily precise gene editing in human cells

Over just a few short years the CRISPR gene-editing technique has revolutionized science, affecting everything from medicine to agriculture. Two new …

Anti-aging stem cell treatment proves successful in early human trials

The results of two human clinical trials into a stem cell therapy that can reverse symptoms of age-associated frailty have been published, and the …

Medicine

CRISPR 2.0 Is Here, and It’s Way More Precise

You’ve probably heard of the molecular scalpel CRISPR-Cas9, which can edit or delete whole genes. Now, scientists have developed a more precise …

Genetics

The Speedy Workout That Changes Your Brain

You probably don’t need to read another article extolling the virtues of regular exercise. If you, like the vast majority of people in the U.S., …

From skin to brain: Stem cells without genetic modificationA discovery, several years in the making,

A discovery, several years in the making, by a University at Buffalo research team has proven that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain.<p>The applications could be very significant, from studying genetic diseases in a dish to generating possible regenerative cures from the patient’s own cells.<p>“It’s actually quite remarkable …

Making an older brain younger by manipulating a single gene

As we age, our brains lose plasticity, which is their ability to adapt to behavioral, physical, or environmental changes. This can have negative …

Neuroscience

Brain cells found to control aging

Scientists have found that stem cells in the brain's hypothalamus govern how fast aging occurs in the body. The finding, made in mice, could lead to …

Longevity

Report: Oregon researchers use CRISPR to edit genes in human embryos

Chinese researchers crossed a threshold last year when they used CRISPR-Cas9 gene-editing tools to modify human embryos, and now Oregon researchers …

Study shows protein in human umbilical cord blood rejuvenates old mice’s impaired learning, memory

Umbilical cord blood from human newborns, and in particular a single protein contained in it, boosted old mice’s brain function and cognitive …

What If (Almost) Every Gene Affects (Almost) Everything?

Three Stanford scientists have proposed a provocative new way of thinking about genetic variants, and how they affect people’s bodies and health.<p>In 1999, a group of scientists scoured the genomes of around 150 pairs of siblings in an attempt to find genes that are involved in autism. They came up …

Genetics

CRISPR Gene-Editing Might Cause Thousands of Unintended Mutations

The popular genetic engineering tool could cause hundreds or thousands of unwanted mutations, potentially creating random side effects.<p>Perhaps the largest medical breakthrough this side of the Human Genome Project has been the invention of CRISPR, a technique for rewriting entire sections of DNA. …

Genetics

Lab Mice Can Live Forever. Soon, So Will You.

I’m going to show you one experiment which has given us confidence that this can happen. This involves putting to mice together in what we call …

Longevity

Meet CRISPR’s Younger Brother, SHERLOCK

One of CRISPR-cas9’s inventors has just announced the arrival of an inexpensive, portable diagnostic tool: SHERLOCK.<br>Read More

Genetics

Crispr Creator Jennifer Doudna on the Promises—and Pitfalls—of Easy Genetic Modification

For $150, you can buy a Crispr kit online and use it to engineer heartier gut bacteria in your kitchen. That’s thrilling, but the technology is …

Causes of baldness, gray hair identified

A study of a rare genetic disease may have yielded a cure for hair graying and baldness, after researchers unintentionally discovered the mechanisms …

Biology

Would You Edit Your Babies’ Genes to Keep Them Healthy?

Two week ago, I asked readers, “Will Editing Your Baby’s Genes Be Mandatory?” That is to say, parents are sometimes charged with crimes when religious beliefs cause them to deny their child lifesaving antibiotics, or an appendectomy, or a blood transfusion. In the future, if and when editing a …

Scientists use gene editing to eliminate HIV DNA in live mice

A team of scientists have snipped away HIV DNA from the genome of live mice using a CRISPR system, and the rodents lived to (kinda) tell the tale. It's still much too early to call the method a possible cure, but the fact that it worked on a living animal opens up a lot of possibilities. Will it …

Genetics

Alzheimer's disease progression predicted by gene mutation

Research, published today in the journal <i>Neurology</i>, describes how mutations in a specific gene that codes for a neural growth factor appear to predict …

Scientists Surprised to Find No Two Neurons Are Genetically Alike

The past few decades have seen intensive efforts to find the genetic roots of neurological disorders, from schizophrenia to autism. But the genes …

Genetics

Exercise-in-a-pill increases endurance, fat burning

It's well known that the way to increase fitness and endurance is through training, but what if the same effects could be achieved with a drug, a …

Closer to a cure: CRISPR cuts HIV from its cellular hideout

Last year, researchers at Temple University and the University of Pittsburgh unveiled a proof-of-concept study that described how the CRISPR-Cas9 …

Genetics

Musclebound mice study brings "exercise pill" a step closer

New research could mean that a pill to provide some of the same health benefits as exercise could eventually move from fantasy to reality. One day we …

New stem cell invented that can grow into any tissue in the body, study finds

Salk Institute and Chinese researchers said they have created a new kind of stem cell, one that is more versatile than any other grown in the lab.<p>The …

Biology

An artificial womb successfully grew baby sheep — and humans could be next

The lambs spent four weeks in the external wombs and seemed to develop normally<p>Inside what look like oversized ziplock bags strewn with tubes of blood and fluid, eight fetal lambs continued to develop — much like they would have inside their mothers. Over four weeks, their lungs and brains grew, …

Pregnancy

The Go-To Gene Sequencing Machine With Very Strange Results

When biologist Rahul Sinha started his first independent research project at Stanford last January, he had a single-minded goal. He had just …

First gene therapy drug proves a flop in the market

When UniQure launched the first commercial gene therapy drug, Glybera, it promised a minor revolution in medicine. By using custom viruses to deliver genes, it could reportedly cure a rare disease (lipoprotein lipase deficiency) with just one round of treatment. However, it just didn't live up to …

Medicine

Human umbilical cord blood restores brain function in old mice

It turns out the fountain of youth might be coursing through human umbilical cords. At least that's part of the findings from a team of researchers …

Neuroscience

Researchers Find a Way to Create Cancer-Fighting Cells

Artificial Thymus<p>Many artificial organs are being developed as an alternative to donated organs, which are only temporary solutions that require the …

Cancer