Pharmaceuticals & Biotechnology

By Jim Sabogal | Using #clinicaltrials to make #medicines for #pharma and #biotech

Express Scripts staking out million-dollar gene therapies

(Reuters) - Express Scripts Holding Co (ESRX.O) built a multi-billion enterprise pressuring drug companies to lower their prices for U.S. patients. Now it is quietly building a side business: getting paid to help drug companies dispense a new generation of high-priced drugs.<p>Express Scripts is in …

Pharma

New compounds 'put cancer cells into a permanent sleep'

In a groundbreaking move, a team of researchers from Australia has now developed a class of compounds able to block cancer cells' activity on a …

Cancer Cells

Scandal-hit Chinese vaccine maker Changsheng started falsifying records in 2014: Xinhua

SHANGHAI (Reuters) - Changsheng Bio-technology Co Ltd, a vaccine maker at the center of a safety scandal in China, began falsifying production records for its rabies vaccine in April 2014, state news agency Xinhua reported on Tuesday.<p>Changsheng had mixed some batches with expired solution and did …

China

New drug may improve liver cancer therapy

Researchers from many international institutions have teamed up to design a more effective drug for liver cancer therapy. Their compound may help …

Cancer

How Close Are We, Really, to Curing Cancer with CRISPR?

Followers of science and health news, particularly those with a terminal illness, may get the impression that the dawn of a new, disease-free era is …

Genetics

DNA-testing company 23andMe has signed a $300 million deal with a drug giant. Here's how to delete your data if that freaks you out.

Popular spit-in-a-tube genetics-testing companies like Ancestry and 23andMe can — and frequently do — sell your data to drugmakers. But on Wednesday, one of those partnerships became much more explicit, when the pharmaceutical giant GlaxoSmithKline announced it was acquiring a $300 million stake in …

Molecular Biology

Pharma Scandal Prompts Calls to Put Vaccine Data on a Blockchain - CoinDesk

A scandal around the fraudulent actions of a vaccine manufacturer in China has sparking a heated debate over the last week – and now the Chinese …

Blockchain

Eisai/Biogen to advance Alzheimer's drug, provide fresh hope

(In this July 24th story, corrects paragraphs 3 and 16 to clarify that Eisai executive said the trial generated positive, rather than effective, results at lower doses)<p>(Reuters) - Eisai Co Ltd and Biogen Inc will move forward with late-stage clinical trials of their Alzheimer’s disease drug, …

Alzheimer's Disease

MIT researchers automate drug design with machine learning

Developing and improving medications is typically a long and very involved process. Chemists build and tweak molecules, sometimes aiming to create a new treatment for a specific disease or symptom, other times working to improve a drug that already exists. But it takes a lot of time and a lot of …

Machine Learning

German pharmacist gets 12 years for diluting cancer drugs

BERLIN (AP) — A court in western Germany has sentenced a pharmacist to 12 years in prison for diluting cancer drugs on a massive scale in order to finance his luxury lifestyle.<p>In its ruling Friday, the Essen regional court said defendant Peter S. had manipulated at least 14,000 drugs, the quality …

Biogen Surges After Positive Results in Alzheimer’s Trial

Biogen Inc. surged the most in seven years after an Alzheimer’s drug showed positive results in a large clinical trial, raising hopes for treatment …

Alzheimer's Disease

4 Big Pharma Stocks Amazon Could Disrupt Next

InvestorPlace - Stock Market News, Stock Advice & Trading TipsIt's been long suspected that Amazon was looking to make inroads into the $400 billion …

John Sculley Weighs In On Amazon, Health M&A And The Future Of PBMs

We’ve also all heard about the joint venture of Buffet, Bezos and Dimon (Berkshire – Amazon – JPMorgan Chase) that will be headed by Dr. Atul Gawande, despite not actually knowing what the organization will do exactly. But the context is the same. Big players, coming together in unique ways in the …

Ensure medications come from a trusted source

The modern pharmaceutical supply chain is quite complex. Drugs can and do change hands many times between the manufacturer and patient.<p>For example, …

Sticker Shock: The Real Cost Of America's 10 Most Expensive Drugs

The high price of pharmaceuticals has become a constant topic of conversation in the U.S. As medical costs rise, consumers face greater financial uncertainty. And day after day, both the White House and Congress make promises that they will lower prescription costs to alleviate constituent …

Lilly's lupus treatment succeeds in mid-stage trial

(Reuters) - Eli Lilly & Co said on Wednesday its drug to treat autoimmune disease lupus met the main goal of a mid-stage trial, positioning the drugmaker to begin a bigger study later this year.<p>The data come two weeks after U.S. health regulators approved the drug, baricitinib, under the trade name …

GSK's two-drug HIV treatment meets main goal in late stage studies

(Reuters) - GlaxoSmithKline's two-drug treatment for HIV, the virus that causes AIDS, met its main goal in late stage studies, scoring key points in its rivalry with Gilead in the medical field.<p>The combination of dolutegravir and lamivudine was shown to be as effective as a dolutegravir-based …

FDA sends warning letters to nine online marketers over opioids

(Reuters) - The U.S. Food and Drug Administration on Tuesday sent warning letters to nine online networks operating a total of 53 websites to stop illegally marketing unapproved versions of opioid medications.<p>The regulator said http://bit.ly/2xLmrmB it is taking additional steps with these warning …

AbbVie's rheumatoid arthritis drug succeeds in late-stage study

(Reuters) - Abbvie Inc said on Tuesday its experimental drug met the main goal of halting progression of moderate-to-severe rheumatoid arthritis in a late-stage trial.<p>The drug, upadacitinib, was tested as a monotherapy in patients who have not been treated with chemotherapy agent …

FDA wants to shorten new drug monopolies to cut costs

CHICAGO (Reuters) - In an effort to increase competition and bring down prescription drug prices, FDA Commissioner Dr. Scott Gottlieb wants to speed approval times for rivals to promising new first-to-market medicines.<p>The U.S. Food and Drug Administration chief has made a commitment to speeding up …

FDA chief outlines new ways to speed cancer drug approvals

CHICAGO (Reuters) - The U.S. Food and Drug Administration is taking steps to streamline the approval process for cancer drugs, reviewing clinical trial data up front to make sure applications companies submit are complete.<p>The new approach, outlined on Saturday in a speech by FDA commissioner Dr. …

Move over, CRISPR: MAGESTIC makes for gentler gene-editing

Allowing scientists to make cut-and-paste edits to an organism's genome, the CRISPR gene-editing tool may be powerful, but it's still a bit clumsy. …

Breaking Into the Top 10

Takeda Pharmaceutical Co.’s largest acquisition would catapult the company into the top 10 within the global pharmaceutical industry. Its agreed $62 …

The incredibly frustrating reason there’s no Lyme disease vaccine

Your dog can get vaccinated for Lyme. You cannot.<p>Lyme has quickly become one of the most common infectious diseases in America, with many as 300,000 people infected every year. And public health officials fear the bacterial infection, which jumps from ticks to humans, will only spread farther and …

Public Health

Why We May Lose Generic Drugs

The mood at the annual generic drug industry confab in Orlando in February was especially somber. The discussion during one panel was all about …

Indian Government to Use Blockchain to End Fake Drugs Era

A research conducted by the world health organization (WHO) shows that most of the fake drugs circulating all over the world come from India. …

Healthcare group Sanofi to invest 350 million euros in Canada vaccine facility

PARIS (Reuters) - French healthcare group Sanofi <SASY.PA> is investing 350 million euros ($432.4 million) in a Canadian vaccine facility, which the drugmaker said would help it meet growing demand in this area.<p>Sanofi's new investment will finance the construction of a new state-of-the-art vaccine …

Biotech M&A rolls on as Alexion snaps up Wilson for $855 million

(Reuters) - Alexion Pharmaceuticals (ALXN.O) has agreed to buy Sweden's Wilson Therapeutics (WTX.ST) for 7.1 billion Swedish crowns ($855 million), boosting its line-up of rare disease drugs as a wave of deal-making in the biotechnology sector continues.<p>The U.S. group is acquiring the business …

CVS rolls out new tool to combat rising drug prices

(Reuters) - Drugstore chain CVS Health Corp on Wednesday launched a new tool that will allow pharmacies help customers tackle the soaring cost of drugs by comparing prices of medicines.<p>U.S. healthcare companies, ranging from insurers to drug retailers, are stepping up efforts to combat rising drug …