Jeetender Chugh

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Measuring hydrogen exchange rates in invisible protein excite…

Measuring hydrogen exchange rates in invisible protein excited states<br>+Dong Long, +Guillaume Bouvignies and Lewis E. Kay <br>PNAS, DOI:10.1073/pnas.1405011111<p>Hydrogen exchange rates have become a valuable probe for studying the relationship between dynamics and structure and for dissecting the mechanism by which proteins fold to their native conformation. Typically measured rates correspond to averages over all protein states from which hydrogen exchange can occur. Here we describe a new NMR …

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

Relaxation dispersion of crude oil...

Relaxation dispersion of crude oil...<p>Dispersion of T1 and T2 Nuclear Magnetic Resonance Relaxation in Crude Oils<br>Joseph J. Chen, Martin Hürlimann, Jeffrey Paulsen, Denise Freed, Soumyajit Mandal and Yi-Qiao Song<br>ChemPhysChem, DOI: 10.1002/cphc.201402077<p>Crude oils, which are complex mixtures of hydrocarbons, can be characterized by nuclear magnetic resonace diffusion and relaxation methods to yield physical properties and chemical compositions. In particular, the field dependence, or dispersion, …

Strategy for automated NMR resonance assignment of RNA:…

Strategy for automated NMR resonance assignment of RNA: application to 48-nucleotide K10<br>Barbara Krähenbühl, Peter Lukavsky, Gerhard Wider <br>J Biomol NMR, DOI: 10.1007/s10858-014-9841-3<p>A procedure is presented for automated sequence-specific assignment of NMR resonances of uniformly [13C, 15N] labeled RNA. The method is based on a suite of four through-bond and two through-space high-dimensional automated projection spectroscopy (APSY) experiments. The approach is exemplified with a 0.3 mM sample …

Statistical Mechanics of the Denatured State of a Protein Usi…

Statistical Mechanics of the Denatured State of a Protein Using Replica-Averaged Metadynamics<br>Carlo Camilloni and Michele Vendruscolo <br>J. Am. Chem. Soc., DOI: 10.1021/ja5027584 <br><br>The characterization of denatured states of proteins is challenging because the lack of permanent structure in these states makes it difficult to apply to them standard methods of structural biology. In this work we use all-atom replica-averaged metadynamics (RAM) simulations with NMR chemical shift restraints to …