THE LONGEVITY MAGAZINE

Most recent stories in THE LONGEVITY MAGAZINE

• Purpose: To examine the association between trajectories of physical activity (PA) over 12 years and epigenetic age acceleration (EAA) in 3600 middle-aged and older adults of the Health and Retirement Study. Methods: Latent variable mixture modeling identified subgroups with similar trajectories of vigorous, moderate, and light PA from 2004 to 2016. Six EAAs, including Horvath’s age acceleration, Hannum’s age acceleration, GrimAge acceleration, PhenoAge acceleration, DunedinPoAm acceleration, and ZhangAA were calculated by regressing epigenetic age on chronological age in 2016. Linear regression models tested associations of PA trajectories with EAAs, controlling for age, sex, race, education, smoking, alcohol consumption, and depression. Results: Five trajectories were identified for each PA type. Moderate and light PA trajectories were stable or slightly changed over time. In contrast, vigorous PA trajectories were either consistently low (27.2%), slightly increased at a low level (14.9%), decreased from moderate to low levels (25.9%), increased to a high level (11.9%), or consistently high (20.1%). Moderate PA trajectories were negatively associated with EAA across six epigenetic clocks (p < .01). Light PA trajectories were not associated with any EAA. Vigorous PA trajectories were associated with slower GrimAge acceleration (p = .004) and DunedinPoAm acceleration (p = .03). Participants that showed consistently high or increasing vigorous PA had slower EAA compared to those with consistently low vigorous PA. Conclusion: Moderate and vigorous, but not light, PA trajectories were associated with slower EAAs.

  

  Michael Reuter

  

  6 days ago

  12-Year Physical Activity Trajectories and Epigenetic Age Acceleration Among Middle-Aged and Older Adults - Tingting Liu, Yvette P. Conley, Kirk I. Erickson, Hongyu Miao, Colm G. Connolly, Michael J. Ormsbee, Changwei Li, 2025

  sagepub.com

  Purpose: To examine the association between trajectories of physical activity (PA) over 12 years and epigenetic age acceleration (EAA) in 3600 …

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  Michael Reuter

  

  New study suggests Alzheimer’s may be reversible

  bgr.com - Joshua Hawkins

  For decades, Alzheimer’s disease has been seen as a one-way road, a slow but inevitable decline in memory and thinking. But new research out of …

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  Michael Reuter

  

  Grip strength: The test for your chances of living to 100

  BBC Future - David Cox

  Grip strength is associated with a range of health outcomes, from type 2 diabetes to depression. Here’s how to check yours. In a world of technologically-driven longevity clinics with their increasingly sophisticated imaging scans, some of which can cost tens of thousands of dollars, it turns out …

• The effects of smoking, drinking and lack of exercise are felt by the age of 36, new research indicates https://www.tandfonline.com/doi/full/10.1080/07853890.2025.2479233#d1e428

  

  Michael Reuter

  

  Cumulative associations between health behaviours, mental well-being, and health over 30 years

  tandfonline.com - Tiia Kekäläinen

  Both the number of risky health behaviours and the duration of exposure to these behaviours over time may increase the risk of later adverse …

• The exercise paradox - What people get wrong about metabolism

  

  Michael Reuter

  

  What people get wrong about metabolism—an interview with Herman Pontzer

  The Economist

  Do you run, cycle or swim to lose weight? Herman Pontzer, an evolutionary anthropologist who specialises in understanding how humans use energy, …

• Trajectories of Sleep Duration, Sleep Onset Timing, and Continuous Glucose Monitoring in Adults

  

  Michael Reuter

  

  Sleep Duration, Sleep Onset Timing, and Continuous Glucose Monitoring in Adults

  jamanetwork.com - Luqi Shen, Bang-yan Li, Wanglong Gou

  Key Points Question Are distinct sleep status trajectories associated with differential glycemic dynamics in the general population? Findings In this …