Thasso

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thasso, the social theragenomics network in health and disease

thasso the new generation glocalized patient network in theragenomic and personalized medicine and individualized drug safety<p>the new generation …

Personalized Medicine

Breast cancer: Multigene sequencing replaces BRCA tests

<b>May 15, 2018 –</b>An increasing number of women who are diagnosed with breast cancer are opting for multigene sequencing instead of the more limited …

Cancer

Dabrafenib/Trametinib-Combo approved for BRAF-positive anaplastic thyroid cancer

“This is the first FDA-approved treatment for patients with this aggressive form of thyroid cancer, and the third cancer with this specific gene …

Cancer

Chinese arrhythmia in traditional medicine

About the Author<p>Ph.D.; Professor in Pharmacology and Toxicology. Senior expert in theragenomic and personalized medicine and individualized drug …

Medicine

Protection from severe malaria associated with novel genetic polymorphisms

About the Author<p>Ph.D.; Professor in Pharmacology and Toxicology. Senior expert in theragenomic and personalized medicine and individualized drug …

Placebo: A veritable treatment option

<b>February 11, 2018 –</b> Long after cancer treatment ends, many patients continue to deal with one particular symptom that refuses to go away: fatigue. In …

Direct-to-Consumer Genetic Testing: Are Patients Ready?

In any case, please find here below the full article by Matt Smith, unedited and not further commented on. It is well worth reading it in full:<p><b>Are</b> …

Breast Cancer: Performance of prognostic signatures

<b>February 17, 2018 –</b> In a new study, published in JAMA Oncology online on February 15, 2018, a comparison of the performance of 6 prognostic …

Vemurafenib (Zelboraf) for BRAF V600E positive Erdheim-Chester Disease (ECD)

Somewhat astonishing and troubling, at least for this author being concerned with individualized human drug safety issues, is the catalogue of the …

DNMT3B gene variant influences nicotine dependence

<b>December 09, 2017 –</b> Newest research has revealed that a DNMT3B gene variant influences nicotine dependence identified in people of European …

Gene expression and ethnicity: Does it matter?

<b>December 05, 2017 –</b> We are entering the age of precision medicine, in which diagnosis and therapy decisions for each patient will be based on …

Placebomics: Where placebo and genetics meet

<b>December 01, 2017 –</b> The placebome is a new game in town. That is where genetics and the placebo effect meet. The underlying discipline of study may …

The nightmare: Sudden cardiac arrest in competitive sports

<b>November 23, 2017 –</b> We all have heard of it: While in full action of the game, a young soccer player collapsed on the field and died. Same for a …

Cancer is not like cancer: Ethnic background matters

A new study just published in PLOS Genetics shows that multiple myeloma patients of European descent were six times more likely than their …

Are there life-threatening health problems with Limbrel?

Currently, the FDA is investigating serious adverse events involving Limbrel (Flavocoxid). While a range of adverse events have been reported, two …

Obeticholic Acid (Ocaliva): Is there a serious drug safety problem?

<b>September 30, 2017 –</b> Obeticholic acid (Ocaliva) was approved by the American Food & Drug Administration (FDA) in May 2016 for the treatment of …

Medicine

Amish People: Old age because of genetic mutations?

However, the researchers quicly realised that those individuals with a mutation on only one of these copies (i.e., being heterozygous for that …

Genetics

Febuxostat (Uloric): Gout medication with increased risk for heart-related death?

About the Author<p>Ph.D.; Professor in Pharmacology and Toxicology. Senior expert in theragenomic and personalized medicine and individualized drug …

Biomedicine

Abilify MyCite, the first digital pill. Where does all that silicone go?

About the Author<p>Ph.D.; Professor in Pharmacology and Toxicology. Senior expert in theragenomic and personalized medicine and individualized drug …

Personalized Medicine

Treatment for the rare genetic disorder MPS VII approved

MPS VII is a lysosomal storage disorder caused by deficiency of an enzyme called beta-glucuronidase, which causes an abnormal buildup of toxic …

Biotechnology

Spinal Muscular Atrophy: Single-Dose Gene-Replacement Therapy

<b>November 12, 2017 –</b> Spinal muscular atrophy type 1 (SMA1) is a progressive, monogenic motor neuron disease with an onset during infancy that results …

Neurology

Personomics: The Missing Link from Precision Medicine to Personalized Medicine

<b>October 21, 2017 –</b> Just seen on PubMed:<p>Ziegelstein RC<p>J Pers Med 2017 Oct;7(4)<p>PMID: 29035320<p>Abstract<p>It is all about people who one day may turn into …

Personalized Medicine

Childhood brain tumors: Genetic variability amenable to individualized therapy approaches

<b>October 02, 2017 –</b> Seemingly incurable childhood brain tumor is one of the most devastating clinical diagnosis a young patient and her/his family can …

Cancer

Chagas disease: First time approval of a treatment in the US

<b>August 31, 2017 –</b> For the very first time, the American Food & Drug Administration (FDA) granted approval for a treatment of Chagas disease in the …

Genetic Biomarker Tied to Suicide Risk in Schizophrenia

On the molecular level, the SNP rs300774 also contributed to the expression of genes related to cholesterol biosynthesis, and subsequent analyses …

Neuroscience

Lifeomics: Epigenetic DNA methylation-based life insurance?

<b>Mai 07, 2017 –</b> Genetics- and/or genomics-based approaches are penetrating every single aspect of human life. In contrast to the term <b>theragenomics</b> …

Genetics

Bisphosphonates: GGPS1 Mutation and Atypical Femoral Fractures

<b>May 05, 2017 –</b> This report nicely illustrates how, by both clever study design and selection of according phenotypic patients, genetic …

Genetics

Risk of severe if not fatal skin reactions with Pembrolizumab (Keytruda)

Healthcare professionals including oncologists, nurses, hospital pharmacists, emergency room staff, and cancer clinic staff should <b>i)</b> counsel patients …

Immunotherapy

CDH2 gene to cause sudden death in young people

“This is important news for families who have had a young family member suffer a sudden cardiac death, for them to know a genetic cause has been …

Genetics

Brodalumab (Siliq) with a fatal touch: New psoriasis drug approved

<b>February 16, 2017 –</b> The American Food & Drug Administration (FDA) just approved Brodalumab (Siliq) to treat adults with moderate-to-severe plaque …

Mental Health