PLOS Pathogens Pearls

7 Magazines | 618 Articles | 614 Followers | @PLOSPearls | PLOS Pathogens presents an Open Access compendium of "lessons-that-last." This living collection of short, educational, and highly useful articles addresses topics of relevance and importance within the wide-ranging field of pathogens research, with insights for trainees and scientists at all career stages. The collection is also found here:

Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes

by Reuben S. Harris, Brett D. Anderson


Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?

1. Brown G.D., et al., Hidden killers: human fungal infections. Sci Transl Med, 2012. 4(165): p. 165rv13. doi: 10.1126/scitranslmed.3004404. …


Postharvest Disease of Banana Caused by Fusarium musae: A Public Health Concern?

by David Triest, Marijke Hendrickx


Chromatin Biology Impacts Adaptive Evolution of Filamentous Plant Pathogens

1. Seidl MF, Thomma BPHJ. Sex or no sex: evolutionary adaptation occurs regardless. Bioessays. 2014;36: 335–345 doi: 10.1002/bies.201300155. …

Building Viral Replication Organelles: Close Encounters of the Membrane Types

by Peter D. Nagy, Jeroen R. P. M. Strating, Frank J. M. van Kuppeveld


A Sixth Modality of Infectious Disease: Contagious Cancer from Devils to Clams and Beyond

by Michael J. Metzger, Stephen P. Goff


The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage

1. Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC (2012) Hidden killers: human fungal infections. Sci Transl Med 4: 165rv113. doi: …

Carrion’s Disease: More Than a Sand Fly–Vectored Illness

by Maria J. Pons, Cláudia Gomes, Juana del Valle-Mendoza, Joaquim Ruiz


Community-Associated Methicillin-Resistant Staphylococcus aureus : An Enemy amidst Us

1. David M, Daum R. Community-associated methicillin-resistant <i>Staphylococcus aureus</i>: Epidemiology and clinical consequences of an emerging epidemic. …

Fungal Super Glue: The Biofilm Matrix and Its Composition, Assembly, and Functions

1. Flemming H.C. and Wingender J., The biofilm matrix. Nat Rev Microbiol, 2010. 8(9): p. 623–33. doi: 10.1038/nrmicro2415. pmid:20676145<p>2. Chandra …

Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity

by Ryan G. Gaudet, Scott D. Gray-Owen

Immune System

Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans

by Read Pukkila-Worley

Immune System

Compromised Defenses: Exploitation of Epithelial Responses During Viral-Bacterial Co-Infection of the Respiratory Tract

by Jeffrey A. Melvin, Jennifer M. Bomberger


Rampant Cheating by Pathogens?

by Ethan A. Rundell, Saria A. McKeithen-Mead, Barbara I. Kazmierczak


Harnessing the Microbiome to Prevent Fungal Infections: Lessons from Amphibians

by Jenifer B. Walke, Lisa K. Belden


Viral Manipulation of Host Inhibitory Receptor Signaling for Immune Evasion

by Eugenia Z. Ong, Kuan Rong Chan, Eng Eong Ooi


Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei

by Monica R. Mugnier, C. Erec Stebbins, F. Nina Papavasiliou


Standing on the Shoulders of Giant Viruses: Five Lessons Learned about Large Viruses Infecting Small Eukaryotes and the Opportunities They Create

by Steven W. Wilhelm, Samantha R. Coy, Eric R. Gann, Mohammad Moniruzzaman, Joshua M. A. Stough

History of Science

Giant Chloroviruses: Five Easy Questions

by James L. Van Etten, David D. Dunigan


The Buzz about Honey Bee Viruses

by Laura M. Brutscher, Alexander J. McMenamin, Michelle L. Flenniken

Nudix Effectors: A Common Weapon in the Arsenal of Plant Pathogens

by Suomeng Dong, Yuanchao Wang

Life Sciences

Expanding Host Range and Cross-Species Infection of Hepatitis E Virus

by Xiang-Jin Meng

Conquering Neutrophils

by Simon Döhrmann, Jason N. Cole, Victor Nizet

Major Sensing Proteins in Pathogenic Fungi: The Hybrid Histidine Kinase Family

by Anaïs Hérivaux, Yee-Seul So, Amandine Gastebois, Jean-Paul Latgé, Jean-Philippe Bouchara, Yong-Sun Bahn, Nicolas Papon

Life Sciences

The Legacy of Past Pandemics: Common Human Mutations That Protect against Infectious Disease

by Kelly J. Pittman, Luke C. Glover, Liuyang Wang, Dennis C. Ko


Untangling the Diverse and Redundant Mechanisms of Staphylococcus aureus Biofilm Formation

by Marta Zapotoczna, Eoghan O’Neill, James P. O'Gara

A Sweet Response to a Sour Situation: The Role of Soluble Pattern Recognition Receptors in the Innate Immune Response to Invasive Aspergillus fumigatus Infections

by Stefan Bidula, Silke Schelenz

Computer Science

Sporothrix Species Causing Outbreaks in Animals and Humans Driven by Animal–Animal Transmission

by Anderson Messias Rodrigues, G. Sybren de Hoog, Zoilo Pires de Camargo


Commensal–Pathogen Interactions along the Human Nasal Passages

by Silvio D. Brugger, Lindsey Bomar, Katherine P. Lemon


Escaping Host Immunity: New Tricks for Plant Pathogens

by Ren Na, Mark Gijzen