PLOS Pathogens Pearls

7 Magazines | 578 Articles | 581 Followers | @PLOSPearls | PLOS Pathogens presents an Open Access compendium of "lessons-that-last." This living collection of short, educational, and highly useful articles addresses topics of relevance and importance within the wide-ranging field of pathogens research, with insights for trainees and scientists at all career stages. The collection is also found here:

Immunizing against Anogenital Cancer: HPV Vaccines

by Cloe S. Pogoda, Richard B. S. Roden, Robert L. Garcea


Dumpster Diving in the Gut: Bacterial Microcompartments as Part of a Host-Associated Lifestyle

1. Fan C, Cheng S, Liu Y, Escobar CM, Crowley CS, Jefferson RE, et al. Short N-terminal sequences package proteins into bacterial microcompartments. …


Thermal Restriction as an Antimicrobial Function of Fever

1. Mackowiak PA (2000) Physiological rationale for suppression of fever. Clin Infect Dis 31 Suppl 5: S185–S189. CID000193 [pii]; doi: 10.1086/317511. …


Estradiol Enhances CD4 + T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce T h 17 Responses via an IL-1-Dependent Pathway

1. Kaushic C, Roth KL, Anipindi V, Xiu F. Increased prevalence of sexually transmitted viral infections in women: the role of female sex hormones in …


Innate Resistance and Susceptibility to Norovirus Infection

by Johan Nordgren, Sumit Sharma, Anita Kambhampati, Ben Lopman, Lennart Svensson


Correlates of Protection against Norovirus Infection and Disease—Where Are We Now, Where Do We Go?

by Sasirekha Ramani, Mary K. Estes, Robert L. Atmar


Filamentous Fungi in Respiratory Infections. What Lies Beyond Aspergillosis and Mucormycosis?

by Anuradha Chowdhary, Kshitij Agarwal, Jacques F. Meis


Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet

1. Moullan N, Mouchiroud L, Wang X, Ryu D, Williams EG, et al. (2015) Tetracyclines disturb mitochondrial function across eukaryotic models: A call …


Tick–Host–Pathogen Interactions: Conflict and Cooperation

1. de la Fuente J, Estrada-Peña A, Venzal JM, Kocan KM, Sonenshine DE. Overview: Ticks as vectors of pathogens that cause disease in humans and …


In Vivo Transcriptional Profiling of Human Pathogenic Fungi during Infection: Reflecting the Real Life?

by Stefanie Allert, Sascha Brunke, Bernhard Hube


Modulation of Host Angiogenesis as a Microbial Survival Strategy and Therapeutic Target

1. Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011;473: 298–307. doi: 10.1038/nature10144. …

Virus–Host Interactions and the ARTD/PARP Family of Enzymes

1. Vyas S, Chang P. New PARP targets for cancer therapy. Nat Rev Cancer. 2014;14: 502–509. doi: 10.1038/nrc3748. pmid:24898058<p>2. Gibson BA, Kraus WL. …

Fusarium: Molecular Diversity and Intrinsic Drug Resistance

by Abdullah M. S. Al-Hatmi, Jacques F. Meis, G. Sybren de Hoog


Viruses Utilize Cellular Cues in Distinct Combination to Undergo Systematic Priming and Uncoating

by Madhu Sudhan Ravindran, Billy Tsai


Cooperation and Conflict in the Plant Immune System

1. Sinapidou E, Williams K, Nott L, Bahkt S, Tor M, et al. (2004) Two TIR:NB:LRR genes are required to specify resistance to <i>Peronospora parasitica</i> …

The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus–Host Interactions

by Douglas R. Wilcox, Richard Longnecker


The Ins and Outs of Rust Haustoria

1. Mendgen K, Struck C, Voegele RT, Hahn M (2000) Biotrophy and rust haustoria. Physiol Mol Plant Pathol 56: 141–145.<p>2. Voegele RT, Struck C, Hahn M, …

Dimorphism in Fungal Pathogens of Mammals, Plants, and Insects

1. Bohse ML, Woods JP (2007) RNA interference-mediated silencing of the <i>YPS3</i> gene of <i>Histoplasma capsulatum</i> reveals virulence defects. Infect Immun 75: …

Life Sciences

Disease to Dirt: The Biology of Microbial Amyloids

1. Fowler DM, Koulov AV, Balch WE, Kelly JW (2007) Functional amyloid–from bacteria to humans. Trends Biochem Sci 32: 217–224. doi: …

Hell's BELs: Bacterial E3 Ligases That Exploit the Eukaryotic Ubiquitin Machinery

1. Behrends C, Harper JW (2011) Constructing and decoding unconventional ubiquitin chains. Nat Struct Mol Biol 18: 520–528. doi: 10.1038/nsmb.2066<p>2. …

The Role of Horizontal Gene Transfer in the Evolution of the Oomycetes

by Fiona Savory, Guy Leonard, Thomas A. Richards


Human and Plant Fungal Pathogens: The Role of Secondary Metabolites

1. Brakhage AA (2013) Regulation of fungal secondary metabolism. Nat Rev Microbiol 11: 21–32. doi: 10.1038/nrmicro2916<p>2. McDonagh A, Fedorova ND, …

Advances and Challenges in Computational Prediction of Effectors from Plant Pathogenic Fungi

by Jana Sperschneider, Peter N. Dodds, Donald M. Gardiner, John M. Manners, Karam B. Singh, Jennifer M. Taylor


Innate Sensing of Chitin and Chitosan

1. Merzendorfer H (2011) The cellular basis of chitin synthesis in fungi and insects: Common principles and differences. Eur J Cell Biol 90: 759–769. …

Worse Comes to Worst: Bananas and Panama Disease—When Plant and Pathogen Clones Meet

by Nadia Ordonez, Michael F. Seidl, Cees Waalwijk, André Drenth, Andrzej Kilian, Bart P. H. J. Thomma, Randy C. Ploetz, Gert H. J. Kema


Beg, Borrow and Steal: Three Aspects of Horizontal Gene Transfer in the Protozoan Parasite, Cryptosporidium parvum

1. Tyzzer EE. A sporozoan found in the peptic glands of the common mouse. Exp Biol Med. 1907;5:12–3. doi: 10.3181/00379727-5-5<p>2. Tzipori S, Widmer G. …

Emerging Paramyxoviruses: Receptor Tropism and Zoonotic Potential

by Antra Zeltina, Thomas A. Bowden, Benhur Lee


The Diverse Role of NK Cells in Immunity to Toxoplasma gondii Infection

by Jason P. Gigley


Go Forth and Colonize: Dispersal from Clinically Important Microbial Biofilms

1. Monds RD, O'Toole GA (2009) The developmental model of microbial biofilms: ten years of a paradigm up for review. Trends Microbiol 17: 73–87. doi: …

SeXX Matters in Infectious Disease Pathogenesis

by Landon G. vom Steeg, Sabra L. Klein