PLOS Pathogens Pearls

7 Magazines | 608 Articles | 590 Followers | @PLOSPearls | PLOS Pathogens presents an Open Access compendium of "lessons-that-last." This living collection of short, educational, and highly useful articles addresses topics of relevance and importance within the wide-ranging field of pathogens research, with insights for trainees and scientists at all career stages. The collection is also found here:

Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity

by Ryan G. Gaudet, Scott D. Gray-Owen

Immune System

Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans

by Read Pukkila-Worley

Immune System

Compromised Defenses: Exploitation of Epithelial Responses During Viral-Bacterial Co-Infection of the Respiratory Tract

by Jeffrey A. Melvin, Jennifer M. Bomberger


Rampant Cheating by Pathogens?

1. Czechowska K., McKeithen-Mead S., Al Moussawi K., Kazmierczak B. I. (2014). Cheating by type 3 secretion system-negative <i>Pseudomonas aeruginosa</i> …


Harnessing the Microbiome to Prevent Fungal Infections: Lessons from Amphibians

1. McFall-Ngai M, Hadfield MG, Bosch TCG, Carey H V, Domazet-Lošo T, Douglas AE, et al. Animals in a bacterial world, a new imperative for the life …


Viral Manipulation of Host Inhibitory Receptor Signaling for Immune Evasion

1. Kuroki K, Furukawa A, Maenaka K (2012) Molecular recognition of paired receptors in the immune system. Front Microbiol 3: 429. doi: …

Immune system

Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei

1. Cross G.A.M. et al. (2014) Capturing the variant surface glycoprotein repertoire (the VSGnome) of Trypanosoma brucei Lister 427. <i>Mol Biochem</i> …


Standing on the Shoulders of Giant Viruses: Five Lessons Learned about Large Viruses Infecting Small Eukaryotes and the Opportunities They Create

by Steven W. Wilhelm, Samantha R. Coy, Eric R. Gann, Mohammad Moniruzzaman, Joshua M. A. Stough

History of Science

Giant Chloroviruses: Five Easy Questions

by James L. Van Etten, David D. Dunigan


The Buzz about Honey Bee Viruses

by Laura M. Brutscher, Alexander J. McMenamin, Michelle L. Flenniken

Nudix Effectors: A Common Weapon in the Arsenal of Plant Pathogens

1. McLennan AG (2006) The Nudix hydrolase superfamily. Cell Mol Life Sci 63: 123–143. pmid:16378245<p>2. Akiyama M, Maki H, Sekiguchi M, Horiuchi T …


Expanding Host Range and Cross-Species Infection of Hepatitis E Virus

by Xiang-Jin Meng

Conquering Neutrophils

1. Bardoel BW, Kenny EF, Sollberger G, Zychlinsky A. The Balancing Act of Neutrophils. Cell Host Microbe. 2014;15(5):526–36. doi: …

Major Sensing Proteins in Pathogenic Fungi: The Hybrid Histidine Kinase Family

1. Mizuno T, Wurtzel ET, Inouye M. Osmoregulation of gene expression. II. DNA sequence of the <i>envZ</i> gene of the <i>ompB</i> operon of <i>Escherichia coli</i> and …


The Legacy of Past Pandemics: Common Human Mutations That Protect against Infectious Disease

1. Allison AC. Protection afforded by sickle-cell trait against subtertian malareal infection. Br Med J. 1954;1(4857):290–4. Epub 1954/02/06. …

Untangling the Diverse and Redundant Mechanisms of Staphylococcus aureus Biofilm Formation

by Marta Zapotoczna, Eoghan O’Neill, James P. O'Gara

A Sweet Response to a Sour Situation: The Role of Soluble Pattern Recognition Receptors in the Innate Immune Response to Invasive Aspergillus fumigatus Infections

1. Schelenz S, Barnes RA, Barton RC, Cleverley JR, Lucas SB, et al. (2015) British Society for Medical Mycology best practice recommendations for the …

Immune System

Sporothrix Species Causing Outbreaks in Animals and Humans Driven by Animal–Animal Transmission

1. Schenck BR. On refractory subcutaneous abscesses caused by a fungus possibly related to the <i>Sporotricha</i>. Bull Johns Hopkins Hosp. 1898;9:286–90.<p>2. …


Commensal–Pathogen Interactions along the Human Nasal Passages

1. Casadevall A, Pirofski LA. What is a host? Incorporating the microbiota into the damage-response framework. Infect Immun. 2015;83(1):2–7. doi: …

Escaping Host Immunity: New Tricks for Plant Pathogens

1. Dangl JL, Horvath DM, Staskawicz BJ (2013) Pivoting the plant immune system from dissection to deployment. Science 341: 746–751. doi: …

Lessons from Nature: Understanding Immunity to HCV to Guide Vaccine Design

1. Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to …

Dissecting Virus Infectious Cycles by Cryo-Electron Microscopy

by Kelly K. Lee, Long Gui


IL-26: An Emerging Proinflammatory Member of the IL-10 Cytokine Family with Multifaceted Actions in Antiviral, Antimicrobial, and Autoimmune Responses

by Emmanuel Stephen-Victor, Helmut Fickenscher, Jagadeesh Bayry

Life Sciences

The Janus-Face of Bacteriophages across Human Body Habitats

by Adam Wahida, Klaus Ritter, Hans-Peter Horz


Impact of the DNA Damage Response on Human Papillomavirus Chromatin

by Dipendra Gautam, Cary A. Moody


Immune Sensing of Lipopolysaccharide in Plants and Animals: Same but Different

by Stefanie Ranf


Anti-infective Surface Coatings: Design and Therapeutic Promise against Device-Associated Infections

by Bryan R. Coad, Hans J. Griesser, Anton Y. Peleg, Ana Traven


Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis

by Laura-Isobel McCall, Jair L. Siqueira-Neto, James H. McKerrow


Immunizing against Anogenital Cancer: HPV Vaccines

by Cloe S. Pogoda, Richard B. S. Roden, Robert L. Garcea


Dumpster Diving in the Gut: Bacterial Microcompartments as Part of a Host-Associated Lifestyle

by Christopher M. Jakobson, Danielle Tullman-Ercek