PLOS Pathogens Pearls

7 Magazines | 612 Articles | 592 Followers | @PLOSPearls | PLOS Pathogens presents an Open Access compendium of "lessons-that-last." This living collection of short, educational, and highly useful articles addresses topics of relevance and importance within the wide-ranging field of pathogens research, with insights for trainees and scientists at all career stages. The collection is also found here:

The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage

1. Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC (2012) Hidden killers: human fungal infections. Sci Transl Med 4: 165rv113. doi: …


Carrion’s Disease: More Than a Sand Fly–Vectored Illness

by Maria J. Pons, Cláudia Gomes, Juana del Valle-Mendoza, Joaquim Ruiz


Community-Associated Methicillin-Resistant Staphylococcus aureus : An Enemy amidst Us

1. David M, Daum R. Community-associated methicillin-resistant <i>Staphylococcus aureus</i>: Epidemiology and clinical consequences of an emerging epidemic. …

Fungal Super Glue: The Biofilm Matrix and Its Composition, Assembly, and Functions

1. Flemming H.C. and Wingender J., The biofilm matrix. Nat Rev Microbiol, 2010. 8(9): p. 623–33. doi: 10.1038/nrmicro2415. pmid:20676145<p>2. Chandra …

United States

Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity

by Ryan G. Gaudet, Scott D. Gray-Owen

Immune Response

Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans

by Read Pukkila-Worley

Immune Response

Compromised Defenses: Exploitation of Epithelial Responses During Viral-Bacterial Co-Infection of the Respiratory Tract

by Jeffrey A. Melvin, Jennifer M. Bomberger

Influenza A virus

Rampant Cheating by Pathogens?

1. Czechowska K., McKeithen-Mead S., Al Moussawi K., Kazmierczak B. I. (2014). Cheating by type 3 secretion system-negative <i>Pseudomonas aeruginosa</i> …

Harnessing the Microbiome to Prevent Fungal Infections: Lessons from Amphibians

1. McFall-Ngai M, Hadfield MG, Bosch TCG, Carey H V, Domazet-Lošo T, Douglas AE, et al. Animals in a bacterial world, a new imperative for the life …


Viral Manipulation of Host Inhibitory Receptor Signaling for Immune Evasion

1. Kuroki K, Furukawa A, Maenaka K (2012) Molecular recognition of paired receptors in the immune system. Front Microbiol 3: 429. doi: …

Immune System

Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei

1. Cross G.A.M. et al. (2014) Capturing the variant surface glycoprotein repertoire (the VSGnome) of Trypanosoma brucei Lister 427. <i>Mol Biochem</i> …


Standing on the Shoulders of Giant Viruses: Five Lessons Learned about Large Viruses Infecting Small Eukaryotes and the Opportunities They Create

by Steven W. Wilhelm, Samantha R. Coy, Eric R. Gann, Mohammad Moniruzzaman, Joshua M. A. Stough

History of Science

Giant Chloroviruses: Five Easy Questions

by James L. Van Etten, David D. Dunigan


The Buzz about Honey Bee Viruses

by Laura M. Brutscher, Alexander J. McMenamin, Michelle L. Flenniken

Nudix Effectors: A Common Weapon in the Arsenal of Plant Pathogens

1. McLennan AG (2006) The Nudix hydrolase superfamily. Cell Mol Life Sci 63: 123–143. pmid:16378245<p>2. Akiyama M, Maki H, Sekiguchi M, Horiuchi T …

Life Sciences

Expanding Host Range and Cross-Species Infection of Hepatitis E Virus

by Xiang-Jin Meng

Conquering Neutrophils

1. Bardoel BW, Kenny EF, Sollberger G, Zychlinsky A. The Balancing Act of Neutrophils. Cell Host Microbe. 2014;15(5):526–36. doi: …

Major Sensing Proteins in Pathogenic Fungi: The Hybrid Histidine Kinase Family

1. Mizuno T, Wurtzel ET, Inouye M. Osmoregulation of gene expression. II. DNA sequence of the <i>envZ</i> gene of the <i>ompB</i> operon of <i>Escherichia coli</i> and …

Life Sciences

The Legacy of Past Pandemics: Common Human Mutations That Protect against Infectious Disease

by Kelly J. Pittman, Luke C. Glover, Liuyang Wang, Dennis C. Ko

Life Sciences

Untangling the Diverse and Redundant Mechanisms of Staphylococcus aureus Biofilm Formation

by Marta Zapotoczna, Eoghan O’Neill, James P. O'Gara


A Sweet Response to a Sour Situation: The Role of Soluble Pattern Recognition Receptors in the Innate Immune Response to Invasive Aspergillus fumigatus Infections

by Stefan Bidula, Silke Schelenz

Computer Science

Sporothrix Species Causing Outbreaks in Animals and Humans Driven by Animal–Animal Transmission

by Anderson Messias Rodrigues, G. Sybren de Hoog, Zoilo Pires de Camargo


Commensal–Pathogen Interactions along the Human Nasal Passages

by Silvio D. Brugger, Lindsey Bomar, Katherine P. Lemon


Escaping Host Immunity: New Tricks for Plant Pathogens

by Ren Na, Mark Gijzen


Lessons from Nature: Understanding Immunity to HCV to Guide Vaccine Design

by Zachary T. Freeman, Andrea L. Cox


Dissecting Virus Infectious Cycles by Cryo-Electron Microscopy

by Kelly K. Lee, Long Gui


IL-26: An Emerging Proinflammatory Member of the IL-10 Cytokine Family with Multifaceted Actions in Antiviral, Antimicrobial, and Autoimmune Responses

by Emmanuel Stephen-Victor, Helmut Fickenscher, Jagadeesh Bayry


The Janus-Face of Bacteriophages across Human Body Habitats

by Adam Wahida, Klaus Ritter, Hans-Peter Horz


Impact of the DNA Damage Response on Human Papillomavirus Chromatin

by Dipendra Gautam, Cary A. Moody


Immune Sensing of Lipopolysaccharide in Plants and Animals: Same but Different

by Stefanie Ranf