PLOS Pathogens Pearls

7 Magazines | 593 Articles | 590 Followers | @PLOSPearls | PLOS Pathogens presents an Open Access compendium of "lessons-that-last." This living collection of short, educational, and highly useful articles addresses topics of relevance and importance within the wide-ranging field of pathogens research, with insights for trainees and scientists at all career stages. The collection is also found here:

The Legacy of Past Pandemics: Common Human Mutations That Protect against Infectious Disease

1. Allison AC. Protection afforded by sickle-cell trait against subtertian malareal infection. Br Med J. 1954;1(4857):290–4. Epub 1954/02/06. …


Untangling the Diverse and Redundant Mechanisms of Staphylococcus aureus Biofilm Formation

by Marta Zapotoczna, Eoghan O’Neill, James P. O'Gara


A Sweet Response to a Sour Situation: The Role of Soluble Pattern Recognition Receptors in the Innate Immune Response to Invasive Aspergillus fumigatus Infections

1. Schelenz S, Barnes RA, Barton RC, Cleverley JR, Lucas SB, et al. (2015) British Society for Medical Mycology best practice recommendations for the …


Sporothrix Species Causing Outbreaks in Animals and Humans Driven by Animal–Animal Transmission

1. Schenck BR. On refractory subcutaneous abscesses caused by a fungus possibly related to the <i>Sporotricha</i>. Bull Johns Hopkins Hosp. 1898;9:286–90.<p>2. …


Commensal–Pathogen Interactions along the Human Nasal Passages

1. Casadevall A, Pirofski LA. What is a host? Incorporating the microbiota into the damage-response framework. Infect Immun. 2015;83(1):2–7. doi: …


Escaping Host Immunity: New Tricks for Plant Pathogens

1. Dangl JL, Horvath DM, Staskawicz BJ (2013) Pivoting the plant immune system from dissection to deployment. Science 341: 746–751. doi: …


Lessons from Nature: Understanding Immunity to HCV to Guide Vaccine Design

1. Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to …


Dissecting Virus Infectious Cycles by Cryo-Electron Microscopy

by Kelly K. Lee, Long Gui


IL-26: An Emerging Proinflammatory Member of the IL-10 Cytokine Family with Multifaceted Actions in Antiviral, Antimicrobial, and Autoimmune Responses

by Emmanuel Stephen-Victor, Helmut Fickenscher, Jagadeesh Bayry


The Janus-Face of Bacteriophages across Human Body Habitats

by Adam Wahida, Klaus Ritter, Hans-Peter Horz


Impact of the DNA Damage Response on Human Papillomavirus Chromatin

by Dipendra Gautam, Cary A. Moody


Immune Sensing of Lipopolysaccharide in Plants and Animals: Same but Different

1. Zipfel C, Felix G. Plants and animals: a different taste for microbes? Curr Opin Plant Biol. 2005;8(4):353–60. Epub 2005/06/01. doi: …


Anti-infective Surface Coatings: Design and Therapeutic Promise against Device-Associated Infections

1. Klevens RM, Edwards JR, Richards CL, Horan TC, Gaynes RP, et al. (2007) Estimating Health Care-Associated Infections and Deaths in U.S. Hospitals, …


Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis

1. Global Burden of Disease Study C. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic …

Immunizing against Anogenital Cancer: HPV Vaccines

by Cloe S. Pogoda, Richard B. S. Roden, Robert L. Garcea


Dumpster Diving in the Gut: Bacterial Microcompartments as Part of a Host-Associated Lifestyle

1. Fan C, Cheng S, Liu Y, Escobar CM, Crowley CS, Jefferson RE, et al. Short N-terminal sequences package proteins into bacterial microcompartments. …


Thermal Restriction as an Antimicrobial Function of Fever

1. Mackowiak PA (2000) Physiological rationale for suppression of fever. Clin Infect Dis 31 Suppl 5: S185–S189. CID000193 [pii]; doi: 10.1086/317511. …

Estradiol Enhances CD4 + T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce T h 17 Responses via an IL-1-Dependent Pathway

1. Kaushic C, Roth KL, Anipindi V, Xiu F. Increased prevalence of sexually transmitted viral infections in women: the role of female sex hormones in …

Innate Resistance and Susceptibility to Norovirus Infection

by Johan Nordgren, Sumit Sharma, Anita Kambhampati, Ben Lopman, Lennart Svensson


Correlates of Protection against Norovirus Infection and Disease—Where Are We Now, Where Do We Go?

by Sasirekha Ramani, Mary K. Estes, Robert L. Atmar


Filamentous Fungi in Respiratory Infections. What Lies Beyond Aspergillosis and Mucormycosis?

by Anuradha Chowdhary, Kshitij Agarwal, Jacques F. Meis


Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet

by Hassan Hashimi, Sabine Kaltenbrunner, Alena Zíková, Julius Lukeš


Tick–Host–Pathogen Interactions: Conflict and Cooperation

by José de la Fuente, Margarita Villar, Alejandro Cabezas-Cruz, Agustín Estrada-Peña, Nieves Ayllón, Pilar Alberdi

In Vivo Transcriptional Profiling of Human Pathogenic Fungi during Infection: Reflecting the Real Life?

by Stefanie Allert, Sascha Brunke, Bernhard Hube


Modulation of Host Angiogenesis as a Microbial Survival Strategy and Therapeutic Target

by Nir Osherov, Ronen Ben-Ami


Virus–Host Interactions and the ARTD/PARP Family of Enzymes

by Chad V. Kuny, Christopher S. Sullivan

Life Sciences

Fusarium: Molecular Diversity and Intrinsic Drug Resistance

by Abdullah M. S. Al-Hatmi, Jacques F. Meis, G. Sybren de Hoog


Viruses Utilize Cellular Cues in Distinct Combination to Undergo Systematic Priming and Uncoating

by Madhu Sudhan Ravindran, Billy Tsai


Cooperation and Conflict in the Plant Immune System

by Eunyoung Chae, Diep T. N. Tran, Detlef Weigel


The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus–Host Interactions

by Douglas R. Wilcox, Richard Longnecker