Joshua Thomas

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Measuring quantitative effects of methylation on transcription factor–DNA binding affinity

• D. Schübeler<p>, Function and information content of DNA methylation.Nature 517, 321–326 (2015).<p>M. M. Suzuki,<br>• A. Bird<p>, DNA methylation landscapes: …

Why Does Heat Kill Cells?

The answer to a longstanding mystery suggests that proteins are far more malleable than previously thought.<p>Above a certain temperature, a cell will collapse and die. One of the most straightforward explanations for this lack of heat hardiness is that the proteins essential to life—the ones that …

Biology

5 Reasons Why The 21st Century Will Be The Best One Ever For Astrophysics

It’s been a staple of science throughout the centuries: the arrogant thinking that we’ve almost arrived at the ultimate answers to our deepest questions. Scientists thought that Newton’s mechanics described everything, until they discovered the wave nature of light. Physicists thought we were …

Physics

Intelligence and Race, in sub-populations

I’ve read a fair number of papers covering race and genes. In fact, before I go farther, here’s a bibliography:<p>In this article, the authors argue …

Octopuses and their cephalopod cousins can edit and recode their own genes

Octopuses have earned a reputation as clever aquatic escape artists. But in addition to being underwater Houdinis, these creatures (and other coleiod …

Biology

OSM (Pronounced Awesome) Hardware Makes DNA in Space

OSM stands for Oligonucleotide Synthesizer designed for use in Microgravity, meaning that it’s a device that makes arbitrary DNA strands (of moderate …

DNA

Trump tax plan leaves Congress, Ryan with heavy lift

WASHINGTON (AP) — President Donald Trump's tax plan leaves much of the heavy lifting to Congress, while ignoring years of hard work by the guy who will have to do a lot of that lifting: House Speaker Paul Ryan.<p>The one-page proposal outlined by the Trump administration Wednesday has something for …

Donald Trump

The Republicans who care about climate change: 'They are done with the denial'

As despair intensifies over Trump’s agenda, the bipartisan Climate Solutions Caucus brings Democrats and Republicans together to break the deadlock<p>The failure of American politics to deal with, or even coherently discuss, climate change was perhaps best illustrated when James Inhofe, a Republican …

Climate

This Single Test Could Identify Every Virus That's Ever Infected You

Blood tests are no fun. Luckily, a group of researchers at Harvard Medical School and Brigham and Women's Hospital, along with others, have come up …

Immune System

We've Lost Sight Of The Most Important Rule In Debating Science

It was almost 100 years ago that the most famous debate in science history took place. The topic up for consideration was the nature of the spiral objects in the sky: were they proto-stars in the process of forming, or were they island Universes, similar to and far outside of our own galaxy? …

Universe
Biology

Meet CRISPR’s Younger Brother, SHERLOCK

Along with Emmanuelle Charpentier and Jennifer Doudna, Feng Zhang is one of the inventors of CRISPR-cas9 — or “CRISPR” for short — the cut-and-paste …

Genetics

The Next International Science Megaproject

Between 1990 and 2003, the world saw the completion of one of the biggest international scientific collaborations that led to the creation of the The …

Genetics

Why Biomedical Companies Are Bleeding Horseshoe Crabs to the Brink of Extinction

Can this creature that's been around since the dinosaurs be saved?<p>Meghan Owings plucks a horseshoe crab out of a tank and bends its helmet-shaped shell in half to reveal a soft white membrane. Owings inserts a needle and draws a bit of blood. "See how blue it is," she says, holding the syringe up …

Natural History

Nanobody System Tags, Grabs, Drags Proteins in the Cell | GEN

Click Image To Enlarge +<p>A nanobody-based system has been used to control intracellular protein localization and enable detailed investigation of wing …

How inkjet printers help transform stem cells - Futurity

Turning stem cells into Schwann cells is key for nerve regeneration research. A new way to do it involves lasers, inkjet printers, and electricity.

Rescue protein gives doomed cells a stay of 'execution': Discovery of the protein that delays cell death could aid transplant survival and offer treatment for cancer, neurodegeneration and infection

Discovery of the protein that delays cell death could aid transplant survival and offer treatment for cancer, neurodegeneration and infection<p>A team …

Neuroscience

Excitement turns to horror as cruise passengers witness orcas harpooned off Caribbean island

Thomson Cruise is considering stopping all whale and dolphin watching tours in the Grenadines after holidaymakers on an outing witnessed two whales being killed. The incident has also put pressure on the small Caribbean nation to review its whaling practices.<p>The 40 passengers, who arrived at the …

Whales
Genetics

Scientists Think They've Traced The Very First Mutations in a Human Life

"Like finding a needle in a haystack."<p>For the first time, scientists have caught a glimpse of the earliest genetic mutations in human …

Genetics

What Do Lungs Do? Help Us Breathe And Maybe Even Produce Blood

Our lungs may be doing much more than just helping us breathe. A series of experiments on mice, carried out by researchers at the University of …

Harvard scientists pinpoint critical step in DNA repair, cellular aging

DNA repair is essential for cell vitality, cell survival, and cancer prevention, yet cells’ ability to patch up damaged DNA declines with age for …

Harvard
Donald Trump

Helix Picks Eleven to Help Introduce Consumers to the Future of DNA Sequencing

The future is in your genes.<p>Bay Area startup Helix believes that individual DNA genomes hold the key to mastering the digital economy, and many …

Genetics

Researchers Created Molecular-Level Nanobots Programmed With DNA

A team of researchers just developed an amoeba-like micro robot that is activated by DNA and has the potential to be used as artificial white blood …

Protein

NIH Grants Akonni $300K to Develop DNA Extraction Device for Molecular TB Testing | GEN

Molecular diagnostics firm Akonni Biosystems won a $300,000 contract from NIH’s National Institute of Allergy and Infectious Diseases (NIAID) to …

Atoms

Master genes trigger cascade of damage to other genes after brain trauma

It wasn't that long ago that sportspeople were expected to simply shake off blows to the head and keep on playing, but evidence continues to mount …

Assembly of embryonic and extra-embryonic stem cells to mimic embryogenesis in vitro

More options<p>Download and print this article for your personal scholarly, research, and educational use.<p>Buy a single issue of <i>Science</i> for just $15 USD.

Embryonic

Scientists Have Grown The World's First Artificial Embryo, And It's Nuts

Building life from scratch.<p>In a world-first experiment, scientists have managed to grow a functional, artificial embryo from scratch, using two types …