Joshua Thomas
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Measuring quantitative effects of methylation on transcription factor–DNA binding affinity
• D. Schübeler<p>, Function and information content of DNA methylation.Nature 517, 321–326 (2015).<p>M. M. Suzuki,<br>• A. Bird<p>, DNA methylation landscapes: …
Why Does Heat Kill Cells?
The answer to a longstanding mystery suggests that proteins are far more malleable than previously thought.<p>Above a certain temperature, a cell will collapse and die. One of the most straightforward explanations for this lack of heat hardiness is that the proteins essential to life—the ones that …
Biology5 Reasons Why The 21st Century Will Be The Best One Ever For Astrophysics
It’s been a staple of science throughout the centuries: the arrogant thinking that we’ve almost arrived at the ultimate answers to our deepest questions. Scientists thought that Newton’s mechanics described everything, until they discovered the wave nature of light. Physicists thought we were …
PhysicsIntelligence and Race, in sub-populations
I’ve read a fair number of papers covering race and genes. In fact, before I go farther, here’s a bibliography:<p>In this article, the authors argue …
Octopuses and their cephalopod cousins can edit and recode their own genes
Octopuses have earned a reputation as clever aquatic escape artists. But in addition to being underwater Houdinis, these creatures (and other coleiod …
BiologyOSM (Pronounced Awesome) Hardware Makes DNA in Space
OSM stands for Oligonucleotide Synthesizer designed for use in Microgravity, meaning that it’s a device that makes arbitrary DNA strands (of moderate …
DNATrump tax plan leaves Congress, Ryan with heavy lift
WASHINGTON (AP) — President Donald Trump's tax plan leaves much of the heavy lifting to Congress, while ignoring years of hard work by the guy who will have to do a lot of that lifting: House Speaker Paul Ryan.<p>The one-page proposal outlined by the Trump administration Wednesday has something for …
Donald TrumpThe Republicans who care about climate change: 'They are done with the denial'
As despair intensifies over Trump’s agenda, the bipartisan Climate Solutions Caucus brings Democrats and Republicans together to break the deadlock<p>The failure of American politics to deal with, or even coherently discuss, climate change was perhaps best illustrated when James Inhofe, a Republican …
ClimateThis Single Test Could Identify Every Virus That's Ever Infected You
Blood tests are no fun. Luckily, a group of researchers at Harvard Medical School and Brigham and Women's Hospital, along with others, have come up …
Immune SystemWe've Lost Sight Of The Most Important Rule In Debating Science
It was almost 100 years ago that the most famous debate in science history took place. The topic up for consideration was the nature of the spiral objects in the sky: were they proto-stars in the process of forming, or were they island Universes, similar to and far outside of our own galaxy? …
UniverseMeet CRISPR’s Younger Brother, SHERLOCK
Along with Emmanuelle Charpentier and Jennifer Doudna, Feng Zhang is one of the inventors of CRISPR-cas9 — or “CRISPR” for short — the cut-and-paste …
GeneticsThe Next International Science Megaproject
Between 1990 and 2003, the world saw the completion of one of the biggest international scientific collaborations that led to the creation of the The …
GeneticsWhy Biomedical Companies Are Bleeding Horseshoe Crabs to the Brink of Extinction
Can this creature that's been around since the dinosaurs be saved?<p>Meghan Owings plucks a horseshoe crab out of a tank and bends its helmet-shaped shell in half to reveal a soft white membrane. Owings inserts a needle and draws a bit of blood. "See how blue it is," she says, holding the syringe up …
Natural HistoryNanobody System Tags, Grabs, Drags Proteins in the Cell | GEN
Click Image To Enlarge +<p>A nanobody-based system has been used to control intracellular protein localization and enable detailed investigation of wing …
How inkjet printers help transform stem cells - Futurity
Turning stem cells into Schwann cells is key for nerve regeneration research. A new way to do it involves lasers, inkjet printers, and electricity.
Rescue protein gives doomed cells a stay of 'execution': Discovery of the protein that delays cell death could aid transplant survival and offer treatment for cancer, neurodegeneration and infection
Discovery of the protein that delays cell death could aid transplant survival and offer treatment for cancer, neurodegeneration and infection<p>A team …
NeuroscienceExcitement turns to horror as cruise passengers witness orcas harpooned off Caribbean island
Thomson Cruise is considering stopping all whale and dolphin watching tours in the Grenadines after holidaymakers on an outing witnessed two whales being killed. The incident has also put pressure on the small Caribbean nation to review its whaling practices.<p>The 40 passengers, who arrived at the …
WhalesScientists Think They've Traced The Very First Mutations in a Human Life
"Like finding a needle in a haystack."<p>For the first time, scientists have caught a glimpse of the earliest genetic mutations in human …
GeneticsWhat Do Lungs Do? Help Us Breathe And Maybe Even Produce Blood
Our lungs may be doing much more than just helping us breathe. A series of experiments on mice, carried out by researchers at the University of …
Harvard scientists pinpoint critical step in DNA repair, cellular aging
DNA repair is essential for cell vitality, cell survival, and cancer prevention, yet cells’ ability to patch up damaged DNA declines with age for …
HarvardHelix Picks Eleven to Help Introduce Consumers to the Future of DNA Sequencing
The future is in your genes.<p>Bay Area startup Helix believes that individual DNA genomes hold the key to mastering the digital economy, and many …
GeneticsResearchers Created Molecular-Level Nanobots Programmed With DNA
A team of researchers just developed an amoeba-like micro robot that is activated by DNA and has the potential to be used as artificial white blood …
ProteinNIH Grants Akonni $300K to Develop DNA Extraction Device for Molecular TB Testing | GEN
Molecular diagnostics firm Akonni Biosystems won a $300,000 contract from NIH’s National Institute of Allergy and Infectious Diseases (NIAID) to …
AtomsMaster genes trigger cascade of damage to other genes after brain trauma
It wasn't that long ago that sportspeople were expected to simply shake off blows to the head and keep on playing, but evidence continues to mount …
Assembly of embryonic and extra-embryonic stem cells to mimic embryogenesis in vitro
More options<p>Download and print this article for your personal scholarly, research, and educational use.<p>Buy a single issue of <i>Science</i> for just $15 USD.
EmbryonicScientists Have Grown The World's First Artificial Embryo, And It's Nuts
Building life from scratch.<p>In a world-first experiment, scientists have managed to grow a functional, artificial embryo from scratch, using two types …