Computational and Structural Biotechnology Journal

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A Review of Matched-pairs Feature Selection Methods for Gene Expression Data Analysis

Abstract<p>With the rapid accumulation of gene expression data from various technologies, e.g., microarray, RNA-sequencing (RNA-seq), and single-cell …

Interplay Between Virulence and Variability Factors as a Potential Driver of Invasive Meningococcal Disease

A review of somatic single nucleotide variant calling algorithms for next-generation sequencing data

Abstract<p>Detection of somatic mutations holds great potential in cancer treatment and has been a very active research field in the past few years, …

An Artificial Neural Network Integrated Pipeline for Biomarker Discovery Using Alzheimer's Disease as a Case Study

Abstract<p>The field of machine learning has allowed researchers to generate and analyse vast amounts of data using a wide variety of methodologies. …

Discovery of Novel Functional Centers With Rationally Designed Amino Acid Motifs

Abstract<p>Plants are constantly exposed to environmental stresses and in part due to their sessile nature, they have evolved signal perception and …

Computational Methods for Assessing Chromatin Hierarchy

Abstract<p>The hierarchical organization of chromatin is known to associate with diverse cellular functions; however, the precise mechanisms and the 3D …

Machine Learning Methods for Histopathological Image Analysis

Abstract<p>Abundant accumulation of digital histopathological images has led to the increased demand for their analysis, such as computer-aided …

FoldX as Protein Engineering Tool: Better Than Random Based Approaches?

Abstract<p>Improving protein stability is an important goal for basic research as well as for clinical and industrial applications but no commonly …

DNA Methylation in Stroke. Update of Latest Advances

Abstract<p>Epigenetic modifications are hereditable and modifiable factors that do not alter the DNA sequence. These epigenetic factors include DNA …

Amplification and bioinformatics analysis of conserved FAD-binding region of L-amino acid oxidase (LAAO) genes in gastropods compared to other organisms

Abstract<p>This study aimed to investigate the conserved FAD-binding region of the L-amino acid oxidase (<i>LAAO</i>) genes in twelve gastropod genera commonly …

Differential Microbial Communities of Omnivorous and Herbivorous Cattle in Southern China

Abstract<p>In Hong Kong, cattle were traditionally raised by farmers as draft animals to plough rice fields. Due to urbanization in the 20th century, …

Bioinformatic Analysis Reveals Conservation of Intrinsic Disorder in the Linker Sequences of Prokaryotic Dual-family Immunophilin Chaperones

Abstract<p>The two classical immunophilin families, found essentially in all living cells, are: cyclophilin (CYN) and FK506-binding protein (FKBP). We …

EMBO Workshop - Microglia 2018 - 18 - 21 March 2018

The final programme, poster numbers and bus schedule are now available for download.<p>Topics<p>Ontogeny and diversity<br>• Microglia physiology<br>• Microglia and the …

Harnessing the power of Big Data, AI, and Precision Medicine | BioData West 2018

<b>BioData World West 2018 Speakers</b><p>×<p>Atul Butte, Director of Institute Computational Health Sciences and Professor, Institute of Computational Health …

Tissue Self-Organisation: Challenging the Systems - 11 - 14 March 2018

The final programme, poster listing and bus schedule are now available for download.<p>Ahead of the meeting, speaker Madeline Lancaster shares how …

Symposium - Systems Biology of Microbial Infection

The <b>systems biology of microbial infection</b> aims to understand the interaction between hosts and pathogens by the <b>integrative combination of experiment</b> …

Biology

Based on CiteScore Percentile Ranking, CSBJ stands at rank #12 in the area of Structural Biology & rank #16 in the area of Biophysics https://t.co/O7U2XRt6r0

Computational and Structural Biotechnology Journal

Biotechnology

Antibody H3 Structure Prediction

Abstract<p>Antibodies are proteins of the immune system that are able to bind to a huge variety of different substances, making them attractive …

What can mathematical modelling say about CHO metabolism and protein glycosylation?

Abstract<p>Chinese hamster ovary cells have been in the spotlight for process optimization in recent years, due to being the major, long established …

Flexible Gastro-intestinal Endoscopy — Clinical Challenges and Technical Achievements

Abstract<p>Flexible gastro-intestinal (GI) endoscopy is an integral diagnostic and therapeutic tool in clinical gastroenterology. High quality standards …

Chagas disease research and development: Is there light at the end of the tunnel?

Abstract<p>Chagas disease, or American trypanosomiasis, is the result of infection by the parasite <i>Trypanosoma cruzi</i>. It is endemic in Latin America, and …

Worsening of Verbal Fluency After Deep Brain Stimulation in Parkinson's Disease: A Focused Review

Abstract<p>Worsening of verbal fluency after treatment with deep brain stimulation in Parkinson's disease patients is one of the most often reported …

Determining the Molecular Pathways Underlying the Protective Effect of Non-Steroidal Anti-Inflammatory Drugs for Alzheimer's Disease: A Bioinformatics Approach

Abstract<p>Alzheimer's disease (AD) represents a substantial unmet need, due to increasing prevalence in an ageing society and the absence of a disease …

Functional Roles for Exosomal MicroRNAs in the Tumour Microenvironment

Abstract<p>Extracellular microRNAs are released from cells both passively and actively. The presence of these microRNAs in the tumour microenvironment …

Exploring Components of the CO2-Concentrating Mechanism in Alkaliphilic Cyanobacteria Through Genome-Based Analysis

Abstract<p>In cyanobacteria, the CO2-concentrating mechanism (CCM) is a vital biological process that provides effective photosynthetic CO2 fixation by …

Flexible Analog Search with Kernel PCA Embedded Molecule Vectors

Abstract<p>Studying analog series to find structural transformations that enhance the activity and ADME properties of lead compounds is an important …

Evaluation of multiple approaches to identify genome-wide polymorphisms in closely related genotypes of sweet cherry (Prunus avium L.)

Abstract<p>Identification of genetic polymorphisms and subsequent development of molecular markers is important for marker assisted breeding of superior …