Cold Spring Harbor Laboratory

123 Added | 2 Magazines | 8 Followers | @CSHL | Cold Spring Harbor Laboratory (CSHL) is a private, not-for-profit research and education institution at the forefront of molecular biology and genetics.

What a real-life science test looks like

<i>By revealing evidence that contradicts the rationale for a new cancer drug, a pair of student scientists learns firsthand that when you do science,</i> …

Research

The initiator of the human DNA replication dance in hi-res

Genome replication is an elaborate DNA dance staged by over 100 molecular performers, and the one that starts the show is known as ORC. Professor …

Genetics

Why some targeted cancer therapies eventually fail

Therapies tailored to the genetics of a particular tumor type are helping lung cancer patients live longer, but cancer usually returns. When it comes …

Cancer

Dark Matter of the Genome, Pt. 1 (Base Pairs Episode 8)

<i>Most of the genome is not genes, but another form of genetic information that has come to be known as the genome’s “dark matter.” In this episode, we</i> …

Expert explains: Can we understand memories at the molecular level?

<i>Memories may seem intangible, but many scientists are working to figure out how they are physically stored in the brain. To achieve this, we’ll need</i> …

Neuroscience

Base Pairs podcast: Dark Matter of the Genome

Most of the genome is not genes, but another form of genetic information that has come to be known as the genome’s “dark matter.” In this episode, we …

Dark Matter

What a real-life science test looks like

By revealing evidence that contradicts the rationale for a new cancer drug, a pair of student scientists learns firsthand that when you do science, …

Science

New art supplies for visualizing tiny machines in the brain

<i>An unusual, but beautiful sight can be found among the figures of a recent scientific paper about some of the tiny machines in our brain: watercolor</i> …

Biology

Key cancer protector has an “Achilles’ heel”

Our bodies, fortunately, employ a number of protectors against cancer. A protein called PTEN is one of the strongest checks against prostate and lung …

Cancer

A cancer like an “oatmeal raisin cookie”

Pancreatic cancer is like an oatmeal-raisin cookie, according to Professor David Tuveson, where the cancer cells are raisins. Just as oatmeal makes …

Cancer

Molecules and a mission: Base Pairs podcast season 1

Just four simple DNA “letters”—the molecules that make up the base pairs of the double helix—are enough to convey the complex instructions for life. …

Genetics

In cancer, one wrong makes a right?

The idea that the wrong number of chromosomes can give rise to cancer dates back over a century. We know now that most cancers do indeed have an …

Cancer

Molecules and a Mission (Bonus Base Pairs Episode)

B: Yeah… “Base Pairs” does take a little explaining… so that’s why we’re here talking to you now.<p>B: Base pairs are molecules.<p>A: End of explanation.<p>B: …

DNA

Reversing Rett syndrome’s impairment of adult learning

Learning impairment is a deeply disabling component of Rett syndrome, a neurodevelopmental disorder seen almost exclusively in females. As a result, …

Developmental Disabilities

A bank for cancer research

Scientists have been saying for years that they could learn a lot more about cancer if they had better access to samples and data from patients under …

Cancer

From the Labdish Blog

Now available for binge-listening: Season 1 of <i>Base Pairs</i>. Read more.<p>http://labdish.cshl.edu/newsletter/from-the-labdish-blog/<p>article<p>en_US<p>LabDish: A …

Basic Research: From Our Labs to Doctors’ Hands

Just before the holidays, the FDA approved a drug that will save lives of young people with the severe form of a disease that causes muscles to waste …

Medicine

Understanding How Zinc Affects How We Think

Poking out from many neurons in the brains are NMDA receptors, whose faulty operation has been implicated in disorders including Alzheimer’s, …

Neuroscience

Our Genome’s Guardian Can Break Bad

A protein known as p53 has long held the grand title of “guardian of the genome” for the protection it provides against cancer-causing mutations. New …

Genetics

For Alan Alda, Science Communication is a State of Mind

Alan Alda, famous for his role in the classic TV series “M*A*S*H” and the PBS series “Scientific American Frontiers,” recently received a 2016 CSHL …

state of mind

Alan Alda and Roy Vagelos honored at 11th Double Helix Medals Dinner

Alan Alda, known as Hawkeye from the classic TV series <i>M*A*S*H</i> and host of PBS’s <i>Scientific American Frontiers</i>, and Roy Vagelos, retired chairman and …

American Museum of Natural History

More people will say “I used to have cancer”

That’s a major goal for Dr. David Tuveson, the new director of CSHL’s Cancer Center. After seeing too many patients with dismal options as a cancer …

Cancer

The Brain Atlas (Base Pairs Episode 7)

<i>One in six people suffers from a mental disorder, and yet, compared to cancer and infectious disease, neuropsychiatric treatment options have barely</i> …

Neuroscience

For Alan Alda, science communication is a state of mind

<i>Alan Alda, famous for his role in the classic TV series “M*A*S*H” and the PBS series “Scientific American Frontiers,” recently received a 2016 CSHL</i> …

Science

Get busy or get RNAi

All cells are either busy reproducing or “quiescently” waiting to reproduce. The latter category includes many critical cells in our bodies, like …

Biology

Emma’s Story: with science on her side, one little girl finds hope

Emma’s prognosis was grim. Spinal Muscular Atrophy (SMA) was crippling her and it seemed that nothing could stop it. That’s now changing thanks to an …

Science

No (real) moustache required to join the “Movember” party

Prostate cancer is the most common non-skin cancer among American men, but most of the prostate cancer researchers at CSHL have zero risk of …

Cancer

Cancer can hijack our web-slinging immune cells

Immune cells called neutrophils have an amazing weapon: they can shoot out webs of DNA to capture invaders. But if neutrophils are Spider-Man, cancer …

Cancer

The case for investing in young scientists

When he was just 27 years old, Adrian Krainer was offered the opportunity to run his own lab at CSHL. Research by his team has led to the development …

Health

No (real) moustache required to join the “Movember” party

<i>Prostate cancer is the most common non-skin cancer among American men, but most of the prostate cancer researchers at CSHL have zero risk of</i> …

Cancer