Alex Mann

30 Flips | 5 Magazines | 54 Followers | @AlexMann2014 | Keep up with Alex Mann on Flipboard, a place to see the stories, photos, and updates that matter to you. Flipboard creates a personalized magazine full of everything, from world news to life’s great moments. Download Flipboard for free and search for “Alex Mann”

How Do Viruses Interact with Stress-Associated RNA Granules?

1. Anderson P, Kedersha N (2009) RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol 10: …

The Role of Chemokines during Viral Infection of the CNS

1. Lane TE, Asensio VC, Yu N, Paoletti AD, Campbell IL, et al. (1998) Dynamic regulation of alpha- and beta-chemokine expression in the central …

Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms

<b>Citation:</b> Broz P, Monack DM (2013) Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms. PLoS Pathog 9(2): e1003144. …

Antimicrobial Peptides: Primeval Molecules or Future Drugs?

1. Giuliani A, Pirri G, Nicoletto S (2007) Antimicrobial peptides: an overview of a promising class of therapeutics. Cent Eur J Biol 2: 1–33.<p>2. …

The Inflammasomes

1. Lamkanfi M, Festjens N, Declercq W, Vanden Berghe T, Vandenabeele P (2007) Caspases in cell survival, proliferation and differentiation. Cell …

Copper at the Front Line of the Host-Pathogen Battle

1. Rubino JT, Franz KJ (2012) Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function. J Inorg Biochem …

Sleeping with the Enemy: How Intracellular Pathogens Cope with a Macrophage Lifestyle

1. Nandan D, Yi T, Lopez M, Lai C, Reiner NE (2002) <i>Leishmania</i> EF-1alpha activates the Src homology 2 domain containing tyrosine phosphatase SHP-1 …

Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens

1. Hood MI, Skaar EP (2012) Nutritional immunity: transition metals at the pathogen-host interface. Nat Rev Microbiol 10: 525–537.<p>2. Terry LJ, Vastag …

Self and Non-self Discrimination of Intracellular Membranes by the Innate Immune System

1. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124: 783–801.<p>2. Janeway CA Jr (1989) Approaching the …

Bacterial Survival Amidst an Immune Onslaught: The Contribution of the Staphylococcus aureus Leukotoxins

1. Menestrina G, Dalla Serra M, Comai M, Coraiola M, Viero G, et al. (2003) Ion channels and bacterial infection: the case of beta-barrel …

Five Mechanisms of Manipulation by Bacterial Effectors: A Ubiquitous Theme

1. Husnjak K, Dikic I (2012) Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem 81: 291–322.<p>2. Dean P …

The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts

1. Kehl-Fie TE, Skaar EP (2009) Nutritional immunity beyond iron: a role for manganese and zinc. Curr Opin Chem Biol 14: 218–224.<p>2. Bullen JJ, …

Colonization Resistance: Battle of the Bugs or Ménage à Trois with the Host?

1. Lawley TD, Walker AW (2013) Intestinal colonization resistance. Immunology 138: 1–11.<p>2. Bohnhoff M, Drake BL, Miller CP (1954) Effect of …

Toll-Like Receptors Promote Mutually Beneficial Commensal-Host Interactions

1. Abreu MT (2010) Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol …

Microbiology

Understanding Human Variation in Infectious Disease Susceptibility through Clinical and Cellular GWAS

1. Raychaudhuri S (2011) Mapping rare and common causal alleles for complex human diseases. Cell 147: 57–69.<p>2. Allison AC (1954) Protection afforded …

The Microbiota and Allergies/Asthma

1. Wills-Karp M, Santeliz J, Karp CL (2001) The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol 1: 69–75.<p>2. …

Signalling C-Type Lectins in Antimicrobial Immunity

1. Drummond RA, Saijo S, Iwakura Y, Brown GD (2011) The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. Eur J Immunol 41: 276–281.<p>2. …

Polyphosphate and Its Diverse Functions in Host Cells and Pathogens

1. Rao NN, Gomez-Garcia MR, Kornberg A (2009) Inorganic polyphosphate: essential for growth and survival. Annu Rev Biochem 78: 605–647.<p>2. Docampo R, …

Innate Immune Sensing of DNA

1. Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140: 805–820.<p>2. Hornung V, Latz E (2010) Intracellular DNA …

Evolution of Th2 Immunity: A Rapid Repair Response to Tissue Destructive Pathogens

1. Thomas GR, McCrossan M, Selkirk ME (1997) Cytostatic and cytotoxic effects of activated macrophages and nitric oxide donors on <i>Brugia malayi</i>. …

Fifty Shades of Immune Defense

1. Kurtz J, Franz K (2003) Innate defence: evidence for memory in invertebrate immunity. Nature 425: 37–38.<p>2. McTaggart SJ, Wilson PJ, Little TJ …

The Role of Mast Cells in the Defence against Pathogens

1. Abraham SN, St John AL (2010) Mast cell-orchestrated immunity to pathogens. Nat Rev Immunol 10: 440–452.<p>2. Dawicki W, Marshall JS (2007) New and …

Burning Down the House: Cellular Actions during Pyroptosis

1. Netea MG, Simon A, van de Veerdonk FLV, Kullberg BJ, Van der Meer J, et al. (2010) IL-1beta Processing in Host Defense: Beyond the Inflammasomes. …

Exploiting and Subverting Tor Signaling in the Pathogenesis of Fungi, Parasites, and Viruses

1. Heitman J, Movva NR, Hall MN (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253: 905–909.<p>2. Shertz CA, …

Host Susceptibility Factors to Bacterial Infections in Type 2 Diabetes

1. Dooley KE, Chaisson RE (2009) Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect Dis 9: 737–746.<p>2. Bader MS (2008) …

Public Health

Disease to Dirt: The Biology of Microbial Amyloids

1. Fowler DM, Koulov AV, Balch WE, Kelly JW (2007) Functional amyloid–from bacteria to humans. Trends Biochem Sci 32: 217–224.<p>2. Chapman MR, Robinson …

Asthma and the Diversity of Fungal Spores in Air

1. Fröhlich-Nowoisky J, Pickersgill DA, Després VR, Pöschl U (2009) High diversity of fungi in air particulate matter. Proc Natl Acad Sci U S A 106: …

News from the Fungal Front: Wall Proteome Dynamics and Host–Pathogen Interplay

1. Klis FM, de Koster CG, Brul S (2011) A mass spectrometric view of the fungal wall proteome. Future Microbiol 6: 941–951.<p>2. Heilmann CJ, Sorgo AG, …

Innate Lymphoid Cells: New Players in IL-17-Mediated Antifungal Immunity

1. Gaffen SL (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol 9: 556–567.<p>2. Puel A, Cypowyj S, Marodi L, Abel L, Picard …

Immune Regulation during Helminth Infections

1. Medzhitov R, Schneider DS, Soares MP (2012) Disease tolerance as a defense strategy. Science 335: 936–941.<p>2. Little TJ, Shuker DM, Colegrave N, …